This handbook is primarily designed for scientists and technicians without formal pharmacokinetics/pharmacodynamics (PK/PD) training, who work in an industrial setting. PK/PD are integral aspects for investigating the disposition and pharmacological efficacy of drugs under various experimental and clinical conditions.

The book is a primary desktop reference and contains easy-to-understand guidance for PK/PD issues, study design, and data interpretation. PK/PD are integral aspects for investigating the disposition and pharmacological efficacy of drugs under various experimental and clinical conditions.

Contents:

1. Introduction
2. Pharmacokinetic study design and data interpretation
3. New approaches for high throughput in vivo exposure screening
4. Absorption
5. Distribution
6. Clearance
7. Protein binding
8. Metabolism
9. Biliary excretion
10. Nonlinear pharmacokinetics
11. Pharmacodynamics and PK/PD relationships
12. Prediction of pharmacokinetics in humans
13. Animal physiology
14. Glossary
15. Appendix A: Important pharmacokinetic equations
16. Appendix B: Typical pharmacokinetic issues and their potential causes
17. Appendix C: References for laboratory animal sciences

Index

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