edited by
Beverly J. McCabe,
Eric H. Frankel
and Jonathan J. Wolfe

Features:

• Presents basic concepts, terminology, and clinical issues to promote effective communication across discipline lines
• Identifies new foods, supplements, and ethnic dishes that may contribute significantly to food-drug interactions
• Explores specific topics such as diseases, disorders, and lifestyle choices
• Provides practical models and tools for learning, planning, and implementing programs to prevent interactions
• Includes appendices that provide a quick reference for important values, formulas, patient assessment and education tools

Handbook of Food-Drug Interactions is an interdisciplinary guide to the prevention and correction of negative food-drug interactions. Rather than simply list potential food-drug interactions, this book provides explanations and gives specific recommendations based on the frequency and severity of reactions.

Contents

1. Pharmacy: Basic Concepts
   • Background View of Drugs
   • The Perfect Medication
   • Drug Delivery and Administration
   • Dosage Form
   • Compounding: What's Old is New Again
   • Pharmacokinetics
   • Pharmacodynamics

2. Biopharmaceutics of Orally Ingested Products
   • Pharmacokinetic Parameters
   • Gastrointestinal Physiological Response to Ingested Foods and Liquids

3. Drug Interactions: Basic Concepts
   • Types and Mechanisms of Drug-Drug and Drug-Nutrient Interactions
   • Unclassified Interactions of Nutritional Status and Drugs

4. Nutrition and Metabolism
   • Ingestion and Absorption Concepts
   • Absorption and Digestion
   • Digestion
   • Metabolism
   • Elimination

5. Food and Nutrition Update
   • Introduction to Nutrition as Foods
   • Nutrient Recommendations
   • Uses of the Dietary Reference Intakes
   • Dietary Guidelines for Planning
   • Assessment of Diet Quality
   • Nutrition Labeling and Health Claims
   • Functional Foods
   • Food Safety
   • Consumer Health Information
   • Future Trends

6. Monitoring Nutritional Status in Drug Regimens
   • Major Drug-induced Malnutrition
   • Nutrients Commonly Affected by Drugs
   • Clinical or Medical History
   • Drug History
   • Diet History
   • Physical Examination for Drug-induced Malnutrition
   • Malabsorption
   • Anemia
   • Neuropathies
   • Dermatitis
   • Bone Disease
   • Gastrointestinal Disease
   • Chronic Diseases
   • Side Effects and Impact on Dietary Intake by Drug Category
   • Digestive Diseases
   • Respiratory Agents
   • Immunosuppressants
   • Psychotropic Agents
   • Food and Supplement Precautions

7. Gastrointestinal and Metabolic Disorders and Drugs
   • Medications Used to Treat Disorders of the Mouth and Throat
   • Gastrointestinal Disease States
   • Medications Used to Treat Metabolic Disorders:
   • Appetite Enhancers
   • Enzyme Replacements
   • Drugs Affecting Fluid Balance
   • Diabetes Insipidus

8. Drug Interactions in Nutrition Support
   • Drug-induced Metabolic Alterations in Nutrition Support Patients
   • Drug Interactions Specific to Patients Receiving Parenteral Nutrition
   • Drug Interactions Specific to Patients Receiving Enteral Nutrition
   • Medication dosage Form Issues
   • Admixing Drugs With the Enteral Feeding Formula
   • Medications Clogging the Feeding Tube
   • Enteral Tube Feeding Intolerance: Medication Culprits
   • Monitoring and Management Strategies for Drug Interactions in Nutrition Support Patients

9. Alcohol: Interactions with Nutrition and Drugs
   • Kinetics
   • Alcohol Consumption Patterns
   • Effects of Alcohol Consumption on Nutrtion
   • Effects of Alcohol Consumption on Particular Nutrients
   • Alcohol and Disease Induction

10. Nutrition and Drug Regimens in Older Persons
    • Nutritional Assessment Overview
    • Cost Effective Prevention in the Elderly
    • Basic Definitions in Nutrition Assessment
    • Incorporation of Nutritional Assessment into the Traditional History/Physical/Laboratory
    • Identifying Those Who Need Nutrition Support
    • Nutrition Support, Supplementation, and Replacement
    • Overview of Nutrition Support
    • Indications for Nutrition Support
    • Energy and Protein Requirements
    • Nutrition Support: Walking the Talk
    • Four Stages of Nutrition Support

11. Obesity and Appetite Drugs
    • Defining Obesity
    • Etiology of Obesity
    • Management of Obesity
    • Over the Counter Medications
    • Prescription Appetite Suppressant Drugs

12. Nonprescription Drugs and Nutrient Interactions
    • Self Care
    • Effect of Food/Nutrients on Medication Absorption
    • Effect of Food/Nutrients on Medication Metabolism
    • Effect of Food/Nutrients on Medication Excretion
    • Effect of Medication on Food/Nutrients Absorption
    • Effect of Medication on Food/Nutrients Metabolism
    • Effect of Medication on Food/Nutrients Excretion

13. Herbal and Dietary Supplement Interactions with Drugs
    • St. John's Wort (Hypericum perforatum)
    • Garlic (Allium sativum)
    • Ginkgo Biloba
    • Panax Ginseng
    • Milk Thistle (Silybum marianum)
    • Licorice (Glycyrrhiza glabra)
    • Ephedra (Ma Huang)
    • Disconnect between in vitro and in vivo Findings
    • Culinary Herbs and Mineral Supplements

14. Dietary Counseling to Prevent Food-Drug Interactions
    • SAFER : Source, Assessment, Foods, Evaluation, and Review
    • Practical Issues: Priorities for Dietary Assessment and Counseling
    • Food and Drug Interaction Education
    • Food Safety:
    • Biogenic Amines: A critical review

15. Prevention of Drug-Food Interactions
    • Considerations Before Dispensing
    • Averting Drug-Food Interactions
    • Weaving the Safety Net
    • The Professional Caregiver's Role in Coordinating Therapy

16. Drug Nutrient Interaction and Joint Commission for Health Care Organizations
    • Responsibility in JCAHO Standards
    • Approaches to Implementation
    • Settings for Implementation
    • Future Implications

17. Computers in Nutrient-Drug Interaction Management; Understanding the Past, the Present and Building a Framework for the Future
    • Background View of Computers
    • Software, the Key to Manipulating and Managing Data
    • Background View of Computers in Pharmacy and Nutrition
    • Computers in Nutrient-Drug Interaction Management
    • Challenges to the Management of Nutrient-drug Interactions
    • Data, the Building Block of Information
    • Computer Applications for Nutrient-Drug Interaction Management
    • Clinical Responsibility

Appendices

• Basic Pharmacy
• Useful Tools for Food and Drug Calculations
• Guidelines for Food and Drugs
• Food Composition Tables
• Screening and History Tools

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