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Handbook of Neurochemistry and Molecular Neurobiology
Brain Energetics, Integration of Molecular and Cellular Processes
Third Edition
by Abel Lajtha

Handbook of Neurochemistry and Molecular Neruobiology provides a comprehensive resource for studies of brain function and metabolism.

This volume focuses on aspects of energy metabolism that unique to the brain and provides a fundamental overview of each area, to define the state-of-the-art in that area as it relates to the brain, and, where appropriate, describe models that portray poorly understood and apparently contradictory data sets with the goal of helping focus attention to experimental resolution of controversial issues.

Contents

Glucose Metabolism in Brain

  • Bioenergetics
  • Glucose, Oxidative Energy Metabolism, and Neural Function in Brain Slices - Glycolysis Plays a Key Role in Neural Activity
  • Pentose Phosphate Pathway and NADPH Metabolism
  • The Cerebral Tricarboxylic Acid Cycles
  • Electron Transport, Structure, Redox-Coupled Protonmotive Activity, and Pathological Disorders of Respiratory Chain Complexes
  • The Mitochondrial F1F0 ATP Synthase

Alternative Substrates

  • The Support of Energy Metabolism in the Central Nervous System with Substrates Other than Glucose

Metabolic Specialization of Brain Cell Types and Compartmentation of Function

  • Anaplerosis
  • Glial-Neuronal Shuttle Systems

Molecular and Cellular Architecture Link Energy Demand with Metabolite Fluxes

  • Cytoplasmic Glycolytic Enzymes, Synaptic Vesicle-Associated Glycolytic ATP-Generating Enzymes: Coupling to Neurotransmitter Accumulation
  • Mitochondrial Architecture and Heterogeneity
  • Coupling of Neuronal Function to Oxygen and Glucose Metabolism Through Changes in Neurotransmitter Dynamics as Revealed with Aging, Hypoglycemia, and Hypoxia
  • Coupling of Brain Function and Metabolism: Endogenous Flavoprotein Fluorescence Imaging of Neural Activities by Local Changes in Energy Metabolism
  • Coupling of Brain Function to Metabolism: Evaluation of Energy Requirements
  • Energy Consumption by Phospholipid Metabolism: Evauation of Energy Requirements
  • Ion Transport and Energy Metabolism

Regulation of Metabolic Fluxes and Metabolic Shuttling by Neural Environment

  • Acid-Base Transport and pH Regulation
  • Nitric Oxide in Regulation of Mitochondrial Function, Respiration, and Glycolysis
  • Mitochondrial Production of Oxidants and Their Role in the Regulation of Cellular Processes
  • Uncoupling Proteins
  • Actions of Toxins on Cerebral Metabolism at the Cellular Level

Interaction of Mitochondria with Cytosol and Other Organelles

  • Mitochondrial/Cytosolic Interactions via Metabolite Shuttles and Transporters
  • Mitochondrial-Endoplasmic Reticulum Interactions
  • Mitochondria-Nucleus Energetic Communication: Role for Phosphotransfer Networks in Processing Cellular Information
  • Mitochondrial Permeability Transition in the CNS - Composition, Regulation, and Pathophysiological Relevance
  • Mitochondrial Mechanisms of Oxidative Stress and Apoptosis

Genes of Metabolism: Generating, Sustaining, and Modifying the Machinery of Energy Metabolism, Regulation of Gene Expression for Metabolic Enzymes

  • Proteomics
  • Genetics and Gene Expression of Glycolysis
  • Transcriptional Integration of Mitochondrial Biogenesis

Metabolic Control Analysis: Modeling Local Pathway Fluxes, Control Points, System Interactions, Network Interactions

  • Mechanisms and Modeling of Energy Transfer Between Intracellular Compartments
  • Modeling of Regulation of Glycolysis and Overall Energy Metabolism Under a Systems Biology Approach
  • Modeling of Electron Transport: Implications to Mitochondrial Diseases
  • Metabolomics: Concepts and Potential Neuroscience Applications

See also:
Handbook of Neurochemistry and Molecular Neurobiology: Behavioral Neurochemistry and Neuroendocrinology

Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport

Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function

Handbook of Neurochemistry and Molecular Neurobiology: Neuroactive Proteins and Peptides

Handbook of Neurochemistry and Molecular Neurobiology: Practical Neurochemistry Methods

Index

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Handbook of Neurochemistry and Molecular Neurobiology
Brain Energetics, Integration of Molecular Neurobiology
Third Edition
by Abel Lajtha

2007 924 pages $248.00 + shipping
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