Dermatology Book from C.H.I.P.S.

Handbook of
Non-Invasive Methods and the Skin

Second edition
by Jorgen Serup

Firmly established as the leading international reference in this field, Handbook of Non-Invasive Methods and the Skin covers methods used in both clinical and experimental dermatology.


  • Presents topics in a highly structured format to ensure easy and consistent access to information
  • Covers current imaging methods and computer techniques
  • Provides a comprehensive overview of the entire field of research
  • Includes 721 illustrations, 129 tables, and 107 equations
  • Contains systematic reviews by the foremost experts in the field

Handbook of Non-Invasive Methods and the Skin, Second Edition incorporates 69 revised chapters with more than 90 new chapters covering topics such as:

  • Computers, computer technique and image analysis
  • Imaging techniques including clinical photography
  • Legal situation and guidelines behind instrumental use
  • Skin friction
  • Barrier functions
  • Important new techniques such as in vitro confocal microscopy, OCT, Raman spectroscopy, etc
  • Veterinary/animal research use of methods


Section I: General Introduction

  1. Personal Perspectives on Bioengineering and the Skin: The Successful Past and the Brilliant Future
  2. How to Choose and Use Non-Invasive Methods
  3. A Practical Guide to Resources on the Internet for the Skin Researcher
  4. The Skin Integument: Variation Relative to Sex, Age, Race, and Body Region
  5. Seasonal Variations and Environmental Influences on the Skin
  6. Non-Invasive Methods and Assessment of Skin Diseases
  7. Standards for Good Clinical Practice (GCP)
  8. Statistical Analysis of Sensitivity, Specificity, and Predictive Value of a Diagnostic Test
  9. Sample Size Calculation
  10. Implementation of a Quality Management System in a Contract Laboratory Working with Non-Invasive Methods
  11. Ethical Considerations

Section II: Technique, Application, and Validation

Skin Surface, Epidermal Structure, and Function Clinical Photography, Surface Imaging Techniques, and Computerized Image Analysis

  1. General Aspects in Medical/Clinical Photography
  2. Use of Compact Digital Camera for Snap Photography
  3. Computerized Image Analysis of Clinical Photos
  4. Magnifying Lens - Non-Invasive Oil Immersion Examination of the Skin
  5. Dermatoscopy
  6. Fiber-Optic Microscopy System for Skin Surface Imaging
  7. Automated Assessment of Pigment Distribution and Color Areas for Melanoma Diagnosis

Skin Surface Contour and Roughness Assessment

  1. Skin Replication for Light and Scanning Electron Microscopy
  2. Skin Surface Replica Image Analysis of Furrows and Wrinkles
  3. Stylus Method for Skin Surface Contour Measurement
  4. Laser Profilometry
  5. Three-Dimensional Evaluation of Skin Surface: Micro- and Macrorelief
  6. The Morphological Tree of the Cutaneous Network of Lines
  7. Comparison of Methodologies for Evaluation of Skin Surface Contour and Wrinkles: Advantages and Limitations

Skin Surface Friction

  1. Tribological Studies on Skin: Measurement of the Coefficient of Friction
  2. Skin Friction Evaluation by Unidirectional Stress Using a Friction Tester
  3. Haptic Finger

Epidermis Structure

  1. Cyanoacrylate Biopsy for Cytologic Evaluation of the Epidermis
  2. High-Resolution Sonography of the Epidermis In Vivo
  3. Optical Coherence Tomography in Dermatology
  4. In Vivo Reflectance Mode Confocal Microscopy in Clinical and Surgical Dermatology
  5. In Vivo Reflectance Mode Confocal Laser Microscopy of Melanocytic Skin Lesions
  6. In Vivo Confocal Microscopy of the Skin Surface Using Fluorescent Markers
  7. In Vivo Confocal Microscopy Application in Product Research and Development
  8. Nuclear Magnetic Resonance (NMR) Examination of the Epidermis In Vivo
  9. Spectrophotometric Intracutaneous Imaging (SIAscopy): Method and Clinical Applications

Epidermis Hydration

  1. Epidermal Hydration: Measurement of High-Frequency Electrical Conductance
  2. Measurement of Epidermal Capacitance
  3. Bioimpedance as a Non-Invasive Method for Measuring Changes in Skin
  4. Comparison of Commercial Electrical Measurement Instruments for Assessing the Hydration State of the Stratum Corneum


  1. Methods to Determine Desquamation Rate, C. Edwards
  2. Application of Adhesive Techniques to Harvest Stratum Corneum Material Dry Skin and Scaling Evaluated by D-Squames and Image Analysis

Barrier Functions and Gradients

  1. Measurement of Transepidermal Water Loss by Semiopen Systems
  2. Measurement of Transepidermal Water Loss by Closed-Chamber Systems
  3. Measurement of Transcutaneous Oxygen Tension
  4. Measurement of Transcutaneous PCO 2
  5. Skin Surface pH: Mechanism, Measurement, Importance
  6. The pH Gradient in the Epidermis Evaluated by Serial Tape Stripping
  7. Techniques for Visualization of Ionic Gradation in Human Epidermis
  8. Skin Chamber Techniques
  9. Microdialysis Methodology for Sampling in the Skin

Skin Surface Microflora

  1. Sampling the Bacteria of the Skin
  2. Mapping the Fungi of the Skin

Dermis Structure and Function: Dermis Structure

  1. High-Frequency Ultrasound Examination of Skin: Introduction and Guide
  2. Ultrasound B-Mode Imaging and In Vivo Structure Analysis
  3. Ultrasound Assessment of Dermal Water and Edema In Vivo
  4. Ultrasound Assessment of Skin Aging
  5. Ultrasound Imaging of Subcutaneous Tissue and Adjacent Structures
  6. Magnetic Resonance Spectroscopy of the Skin
  7. Nuclear Magnetic Resonance Examination of Skin Disorders
  8. Raman Spectroscopy of Skin

Dermis Structure and Function: Mechanical Properties

  1. Identification of Langer's Lines
  2. Suction Chamber Method for Measuring Skin Mechanical Properties: The Dermaflex®
  3. Suction Chamber Method for Measurement of Skin Mechanics: The Cutometer®
  4. Suction Chamber Method for Measurement of Skin Mechanics: The New Digital Version of the Cutometer®
  5. Suction Chamber Method for Measurement of Skin Mechanics
  6. Twistometry Measurement of Skin Elasticity
  7. Levarometry
  8. Indentometry
  9. The Gas-Bearing Electrodynamo Meter
  10. Ballistometry

The Cutaneous Vasculature: Skin Colour and Blood Vessels

  1. Colorimetry
  2. Quasi-L*a*b* Color Measurement from Digital Images
  3. Practical Color Calibration for Dermatoscopic Images
  4. Measurement of Erythema and Melanin Indices
  5. Dynamic Capillaroscopy
  6. Capillaroscopy and Videocapillaroscopy Assessment of Skin Microcirculation: Dermatological and Cosmetic Approaches

The Cutaneous Vasculature: Blood Flow, Vasomotion and Vascular Functions

  1. Laser Doppler Measurement of Skin Blood Flux: Variation and Validation
  2. Examination of Periodic Fluctuations in Cutaneous Blood Flow
  3. Laser Doppler Flowmetry: Principles of Technology and Clinical Applications
  4. Laser Doppler Imaging of Skin
  5. The Heat Wash-In and Heat Wash-Out Technique for Quantitative, Non-Invasive Measurement of Cutaneous Blood Flow Rate
  6. The 133Xenon Wash-Out Technique for Quantitative Measurement of Cutaneous and Subcutaneous Blood Flow Rates
  7. Evaluation of Lymph Flow

The Cutaneous Vasculature: Temperature and Thermoregulation

  1. Faculty of Applied Design and Engineering
  2. Thermal Imaging of Skin Temperature

Neural Supply

  1. Assessment of Cutaneous Pain

Sweat Gland Distribution and Function

  1. Classical Techniques for the Localization of Sweat Glands
  2. Micro-Sensor Mapping of Sudoral Activity and Skin Surface Hydration
  3. Methods for the Collection of Eccrine Sweat
  4. Methods for the Collection of Apocrine Sweat

Sebaceous Glands and Sebum Excretion

  1. The Follicular Biopsy
  2. Measurement of Excreted Sebum Using Sebum-Absorbent Film and an Optical Reader: The TapeAnalyzer
  3. Quantification of Sebum Output Using Sebum-Absorbent Tapes (Sebutapes®)
  4. Optical Measurement of Sebum Excretion Using Opalescent Film Imprint: The Sebumeter®
  5. Gravimetric Technique for Measuring Sebum Excretion Rate (SER)
  6. Fluorescence Photography of Sebaceous Follicles
  7. Methods for Assessment of Follicular Transport in Ex Vivo and In Vivo

Hair, Physical Properties, and Growth Rate

  1. Measurement of Hair Growth
  2. Microscopy of the Hair: The T 875
  3. Photographic and Computerized Techniques for Quantification of Hair Growth
  4. Measurement of the Mechanical Strength of Hair
  5. Evaluating the Strength of Human Hair

Nail Structure and Growth

  1. Methods for Nail Assessment
  2. Measurement of Longitudinal Nail Growth
  3. Measurement of Nail Thickness
  4. Image Analysis of the Nail Surface

Section III: Clinical Experimentation, Evaluation, and Quantification

  1. General Guidelines for Assessment of Skin Diseases
  2. Sodium Lauryl Sulfate (SLS) Testing: ESCD Application and Reading Standards
  3. Instrumental and Computer-Based Methods for Measurement of Surface Area Afflicted with Disease
  4. Instrumental Evaluation of Wheal-and-Flare Reactions
  5. Instrumental Evaluation of Occluded Patch Test Reactions
  6. Light Sources, Sunlight, and Radiation Dosimetry
  7. Phototesting: Phototoxicity and Photoallergy


click here to see books • videos • cd-roms of related interest


Handbook of Non-Invasive Methods and the Skin
Second edition
by Jorgen Serup

2006 • 1,029 pages • $298.95 + shipping
Texas residents please add 6.75 % sales tax

Go to Top of Page

copyright © 1997-2009 Culinary and Hospitality Industry Publications Services