A Comprehensive Guide to Diagnosis and Treatment
edited by
G. William Dec
Considering emerging therapies and ongoing clinical trials, Heart Failure:
- provides a comprehensive overview of the molecular pathogenesis and clinical management of both systolic and diastolic heart failure, including updated references through 2003
- critically evaluates landmark randomized clinical trials of established and novel pharmacological therapies
- addresses evolving indications and contemporary results of surgical heart failure therapies including high risk coronary revascularization, mitral valve repair, and ventricular remodeling procedures
- reviews current indications, complications, and long-term results of cardiac transplantation
- compares the advantages and disadvantages of a variety of current and prototypic left ventricular assist devices
- fills a gap in the literature by analyzing the diagnosis, management, and clinical outcomes for selected populations such as women, the elderly, and minority groupsAudience
Heart Failure authoritatively summarizes the fundamental cellular and molecular abnormalities associated with heart failure, as well as current invasive and noninvasive diagnostic techniques, the latest pharmacological advances, device-based therapies, surgical options, and evolving molecular treatments-surpassing any other text on the topic with concise discussions of recent molecular discoveries in pathophysiology alongside practical clinical approaches to the diagnosis and treatment of heart failure patients.
Contents:
- The genetics of dilated and hypertrophic cardiomyopathies
- Molecular signaling networks underlying cardiac hypertrophy and failure
- Mechanisms of cell death in heart failure
- Excitation-contraction coupling mechanisms in heart failure
- [beta]-Adrenergic signaling in heart failure
- Ventricular remodeling and secondary valvular dysfunction in heart failure progression
- Neurohormonal and cytokine activation in heart failure
- Cardiomyopathies in the adult (dilated, hypertrophic, and restrictive)
- Heart failure with normal systolic function
- The clinical syndrome of heart failure
- Clinical profiles and prognosis in heart failure
- Conventional therapy of chronic heart failure : diuretics, angiotensin-converting enzyme inhibitors, and digoxin
- Conventional therapy of chronic heart failure : beta-adrenergic blockers
- Angiotensin receptor blockers for heart failure
- Role of mineralocorticoid antagonists in patients with heart failure
- New pharmacologic therapies in heart failure : immunotherapy, endothelin-1 antagonists, brain natriuretic peptides, and neurohormonal interventions
- Treatment of diastolic heart failure
- Cardiac resynchronization therapy
- Management of atrial and ventricular arrhythmias in heart failure
- Heart failure in special populations
- Practice guidelines for heart failure management
- Coronary revascularization, mitral valve repair, left ventricular remodeling, procedures and devices
- Long term mechanical circulatory support and cardiac transplantation
- Targeted gene transfer in heart failure
- Cellular transplantation
Index
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