• Zebrafish Hematopoiesis
• Zebrafish Genetics and Hematopoietic Mutants
• Mesoderm Patterning Mutants
• Hematopoietic Stem Mutants
• Differentiation and Proliferation Mutants
• Hypochromic Blood Mutants
• Photosensitive Mutants
• Future Directions

3. Extra- and Intraembryonic HSC Commitment in the Avian Model

• The HSC That Colonise the Hematopoietic Organs Have an Extrinisic Origin
• The Discovery of an Intraembryonic Hematopoietic Site
• Gastrulation and Patterning of the Mesoderm
• Role of the Endoderm
• Hemangioblast nd the Hemogenic Endothelium
• Dual Origin of Aortic ECs
• Manipulating hte Angiopoietic/Hemangiopoietic Commitment
• The Allantois, a Later Source of HSC Colonizing the Bone Marrow

4. Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem Cell Differentiation

• Hemangioblasts
• Transcription Factors and Early Hematopoiesis
• Adoption of the Lymphoid Fate
• Molecular Control of T Lymphopoiesis
• Molecular Control of B Lymphopoiesis
• The Ikaros Family of Transcription Factors
• Contribution of Ikaros to the Hematopoietic Compartments
• Ikaros and Hematopoietic Stem Cells
• Ikaros and Thymocyte Development
• Ikaros: A Threshhold for T Cell Function
• Aiolos: Setting Brakes for B Cells
• Ikaros and Aiolos Running the Lymphoid Chromatin Modifying Machinery
• The Ikaros Family in Avian Lymphohematopoiesis

5. Yolk Sac Development in Mice

• Gastrulation and Yolk Sac Formation
• Blood Island Formation
• Hemangioblast
• Primitive Erythropoiesis
• Development of unipotential hematopoietic Progenitors
• Development of Multipotential Myeloid Progenitors
• Development of Hematopoietic Stem Cells

6. Long-Term Reconstituting Hematopoietic Stem Cell Capacity in the Embryo

• General Principles of Hematopoietic Stem Cell Emergence during Ontogeny
• Emergence of Hematopoietic Stem Cells in the Yolk Sac
• Hematopoietic Stem Cell Ontogeny in the Embryo Proper

7. The Endothelium: The Cradle of Definitive Hematopoiesis?

• The Emergence of Definitive HSCs: Origin and Regulation
• Hemangioblast or Hemogenic Endothelial Cells?

8. Endothelial and Hematopoietic Cells in the Intraembryonic Compartment

• Development of Vasculature
• Development of HCs
• Regulation of Hematopoiesis
• Hemangioblasts: Common Progenitors of HCs and ECs
• Interaction between HSCs and ECs

9. Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo

• Extra- and Intraembryonic Contribution to Hematopoietic Development
• Intraembryonic Hematopoiesis: To the Precise Origin of HSC

10. Hematopoietic Development in Drosophila: A Parallel with Vertebrates

• Drosophila Hemocyte Types and Their Functions
• Hematopoietic Development
• Genetic Control of Hematopoiesis
• Hormonal Control of Hematopoiesis
• Drosophila as a Model System for Understanding Mammalian Hematopoiesis

11. Intraembryonic Development of Hematopoietic Stem Cells during Human Ontogeny: Expression Analysis

• Techniques
• Analysis of Gene Expression Patterns in the Human AGM
• Expression of Receptors and Ligands in the Human AGM
• Expression of Transcription Factors in the AGM
• Expression of Cell Adhesion Molecules in the AGM
• Environmental Expression Patterns in the AGM
• Comparison of AGM and Fetal Lives Expression Patterns

12. Gene and Cell Therapy Involving Hematopoietic Stem Cell

• Hematopoietic Stem Cell Transplantation (HSCT): Generalities
• Gene Therapy
• Severe Combined Immunodeficiency Disease
• Fanconi Anemia
• Chronic Granulomatous Disease
• Hemoglobinopathies
• Conclusions and Perspectives in the Use of HSC for Regenerative Medicine

Index