Stem Cell Technology Book from C.H.I.P.S.

Hematopoietic Stem Cell Development
by Isabelle Godin

Hematopoietic Stem Cell Development brings together articles covering the biology of hematopoietic stem cells during embryonic development, reporting particular aspects of fly, fish, avian and mammalian models.

Thus, Hematopoietic Stem Cell Development allows a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing the conserved trends in development.

Hematopoietic Stem Cell Development culminates with state-of –the art knowledge on hematopoietic development in human species and discussions of the most recent breakthroughs with relevance to both researchers and clinicians.


1. Ventral and Dorsal Contributions to Hematopoiesis in Xenopus

  • Hematopoietic Organs in Xenopus
  • Origins of Hematopoietic Cells in Xenopus
  • Development of hematopoietic Cells in Association with Endothelial Cells in Xenopus
  • Embryonic Signals Involved in Hematopoietic Development in Xenopus

2. Genetic Dissection of Hematopoiesis Using the Zebrafish

  • Zebrafish Hematopoiesis
  • Zebrafish Genetics and Hematopoietic Mutants
  • Mesoderm Patterning Mutants
  • Hematopoietic Stem Mutants
  • Differentiation and Proliferation Mutants
  • Hypochromic Blood Mutants
  • Photosensitive Mutants
  • Future Directions

3. Extra- and Intraembryonic HSC Commitment in the Avian Model

  • The HSC That Colonise the Hematopoietic Organs Have an Extrinisic Origin
  • The Discovery of an Intraembryonic Hematopoietic Site
  • Gastrulation and Patterning of the Mesoderm
  • Role of the Endoderm
  • Hemangioblast nd the Hemogenic Endothelium
  • Dual Origin of Aortic ECs
  • Manipulating hte Angiopoietic/Hemangiopoietic Commitment
  • The Allantois, a Later Source of HSC Colonizing the Bone Marrow

4. Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem Cell Differentiation

  • Hemangioblasts
  • Transcription Factors and Early Hematopoiesis
  • Adoption of the Lymphoid Fate
  • Molecular Control of T Lymphopoiesis
  • Molecular Control of B Lymphopoiesis
  • The Ikaros Family of Transcription Factors
  • Contribution of Ikaros to the Hematopoietic Compartments
  • Ikaros and Hematopoietic Stem Cells
  • Ikaros and Thymocyte Development
  • Ikaros: A Threshhold for T Cell Function
  • Aiolos: Setting Brakes for B Cells
  • Ikaros and Aiolos Running the Lymphoid Chromatin Modifying Machinery
  • The Ikaros Family in Avian Lymphohematopoiesis

5. Yolk Sac Development in Mice

  • Gastrulation and Yolk Sac Formation
  • Blood Island Formation
  • Hemangioblast
  • Primitive Erythropoiesis
  • Development of unipotential hematopoietic Progenitors
  • Development of Multipotential Myeloid Progenitors
  • Development of Hematopoietic Stem Cells

6. Long-Term Reconstituting Hematopoietic Stem Cell Capacity in the Embryo

  • General Principles of Hematopoietic Stem Cell Emergence during Ontogeny
  • Emergence of Hematopoietic Stem Cells in the Yolk Sac
  • Hematopoietic Stem Cell Ontogeny in the Embryo Proper

7. The Endothelium: The Cradle of Definitive Hematopoiesis?

  • The Emergence of Definitive HSCs: Origin and Regulation
  • Hemangioblast or Hemogenic Endothelial Cells?

8. Endothelial and Hematopoietic Cells in the Intraembryonic Compartment

  • Development of Vasculature
  • Development of HCs
  • Regulation of Hematopoiesis
  • Hemangioblasts: Common Progenitors of HCs and ECs
  • Interaction between HSCs and ECs

9. Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo

  • Extra- and Intraembryonic Contribution to Hematopoietic Development
  • Intraembryonic Hematopoiesis: To the Precise Origin of HSC

10. Hematopoietic Development in Drosophila: A Parallel with Vertebrates

  • Drosophila Hemocyte Types and Their Functions
  • Hematopoietic Development
  • Genetic Control of Hematopoiesis
  • Hormonal Control of Hematopoiesis
  • Drosophila as a Model System for Understanding Mammalian Hematopoiesis

11. Intraembryonic Development of Hematopoietic Stem Cells during Human Ontogeny: Expression Analysis

  • Techniques
  • Analysis of Gene Expression Patterns in the Human AGM
  • Expression of Receptors and Ligands in the Human AGM
  • Expression of Transcription Factors in the AGM
  • Expression of Cell Adhesion Molecules in the AGM
  • Environmental Expression Patterns in the AGM
  • Comparison of AGM and Fetal Lives Expression Patterns

12. Gene and Cell Therapy Involving Hematopoietic Stem Cell

  • Hematopoietic Stem Cell Transplantation (HSCT): Generalities
  • Gene Therapy
  • Severe Combined Immunodeficiency Disease
  • Fanconi Anemia
  • Chronic Granulomatous Disease
  • Hemoglobinopathies
  • Conclusions and Perspectives in the Use of HSC for Regenerative Medicine


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Hematopoietic Stem Cell Development
by Isabelle Godin
2006 • 178 pages • $144.00 + shipping
Texas residents please add 6.75 % sales tax

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