Human Development Neurotoxicology describes the most recent developments in the design, execution, and interpretation of human developmental neurotoxicology studies.

Features:

• Offers strategies to incorporate developmental neurotoxicity data into the risk assessment process
• Supplies techniques to enhance and strengthen exposure and endpoint testing and correctly approach data collection and utilization
• Compares animal and human endpoint assessments
• Discusses emerging issues such as endocrine disruptors and pesticides, and the application of neuroimaging techniques in neurotoxicological studies
• Includes a survey of alternative statistical methods to derive 'points of departure' for the development of exposure standards

Contents

Environmental Chemicals

• Methylmercury
• Polychlorinated Biphenyls
• Solvents
• Pesticides

Medicinals

• Retinoids
• Chemotherapeutic Drugs

Recreational Substance Use

• Maternal Smoking During Pregnancy and ETS
• Cocaine

Exposure Assussment and Pharmacokinetic Models

• Metals
• Pesticides
• Drugs of Abuse

Endpoint Assessment

• Parallels Between Animal and Human Models of Nerobehavioral Disorders: General Considerations
• Neuropsycchological Assessment Issues and Strategies
• Role of Neuroimaging
• Childhood Exposures and Adult Disease

Data Analysis and Defining Bases of Individual Suseptibility

• The Experimentalist Perspective
• Applications of Structural Equation Modeling
• The Social-Ecological Perspective. Molecular Mechanisms

Increasing the Relevance and Utility of Data from Developmental Neurotoxicity Studies to Clincal Practice and to Risk Assessment

• Ethical Considerations
• The Political and Economic Contexts
• Clinician Perspective
• Public Health Perspective

Index

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