Human Nucleotide Expansion Disorders represents a comprehensive and up-to-date description of many of the better-studied disorders and discusses molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms.

Contents

Molecular Bases of Nucleotide Expansions

• Mechanisms of DNA Repeat Expansion

Disorders Associated with Non-coding Repeats

• Molecular Correlates of Fragile X Syndrome and FXTAS
• The Neglected Fragile X Mutations: FRAXE and FRAXF
• Friedrich Ataxia
• Dodecamer Repeat Expansion in Progressive Myoclonus Epilepsy 1
• Myotonic Dystrophies Types 1 and 2
• Spinocerebellar Ataxia Type 8
• Recent Progress in Spinocerebellar Ataxia Type 10

Disorders Associated with Coding Repeats

• Polyglutamine Diseases
• The Enigma of Spinocerebellar Ataxia Type 6

Disorders Associated with Repeats in an Undetermined Location

• Spinocerebellar Ataxia Type 12 and Huntington's Disease-Like 2: Clues to Pathogenesis

Postscript

• Current Issues and Therapeutic Prospects

Index

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ORDER NOW Human Nucleotide Expansion Disorders by Michael Fry 2006 • 293 pages • $168.00 + shipping Texas residents please add 6.75% sales tax