Hypocretins helps you become familiar with the themes of cephalopod biology and ecology, and promotes their greater integration into the mainstream of marine science.

Contents

Discovery of the Hypocretins/Orexins and their Receptors

• The Discovery of the Hypocretins: New Hypothalamic Peptides
• Orexin and Orexin Receptors

Animal Models in the Study of the Hypocretinergic System

• Rodent Models of Human Narcolepsy-Cataplexy
• The Canine Model of Narcolepsy

Detailed Anatomy of the Hypocretinergic System and Related Hypothalmic Circuits

• Anatomy of the Hypocretin System
• The Anatomy of Hypocretin Neurons
• Transmitter-Identified Neurons and Afferent Innervation of the Lateral Hypothalmic Area: Focus on Hypocretin and Melanin-Concentrating Hormone

Physiological Consequences of Hypocretin Activation

• Physiological Characteristics of Hypocretin/Orexin Neurons
• The NE System as a Target for Hypocretin Neurons: Implications for Regulation of Arousal
• Hypocretin/Orexin Actions on Mesopontine Cholinergic Systems Controling Behavioral State
• The Aminergic Systems and the Hypocretins
• Effects of Hypocretin/Orexin on the Thalamocortical Activating System

Pharmacology of the Hypocretins and Drug Design

• In Vivo Pharmacology of Orexin (Hypocretin) Receptors
• Intracellular Signal Pathways Utilized by the Hypocretin/Orexin Receptors

The Hypocretins in Narcolepsy and Arousal

• The Hypocretins and Narcolepsy: Pathophysiology and Diagnosis
• An Approach to Determining the Functions of Hypocretin (Orexin)
• Hypocretin in Neuropsychiatric Disorders
• Hypocretin/Orexin and Sleep: Implications for the Pathophysiology of Human Narcolepsy
• Modulation of Cortical Activity and Sleep-Wake States by Hypocretin/Orexin

The Hypocretins in Feeding and Energy Balance

• Regulation of Hypocretin by Metabolic Signals

The Hypocretins in Addiction and Hyperarousal

• Hypocretin and Brain Reward Function
• Orexin/Hypocretin and Opioid Dependence
• Dopamine - Hypocretin/Orexin Interactions: The Prefrontal Cortex and Schizophrenia
• Hypocretin/Orexin in Stress and Arousal

Role of Hypocretins and Peripheral Systems

• The Hypocretins/Orexins and the Hypothalamo-Pituitary-Adrenal Axis
• Orexins (Hypocretins) in the Gut
• Hypocretins in Endocrine Regulation
• The Hypocretins in Cardiovascular Regulation

Index

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ORDER NOW Hypocretins Integrators of Physiological Functions by Luis de Lecea 2005 • 439 pages • $138.00 + shipping Texas residents please add 6.75% sales tax