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Hypocretins
Integrators of Physiological Functions
by Luis de Lecea

Hypocretins helps you become familiar with the themes of cephalopod biology and ecology, and promotes their greater integration into the mainstream of marine science.

Contents

Discovery of the Hypocretins/Orexins and their Receptors

  • The Discovery of the Hypocretins: New Hypothalamic Peptides
  • Orexin and Orexin Receptors

Animal Models in the Study of the Hypocretinergic System

  • Rodent Models of Human Narcolepsy-Cataplexy
  • The Canine Model of Narcolepsy

Detailed Anatomy of the Hypocretinergic System and Related Hypothalmic Circuits

  • Anatomy of the Hypocretin System
  • The Anatomy of Hypocretin Neurons
  • Transmitter-Identified Neurons and Afferent Innervation of the Lateral Hypothalmic Area: Focus on Hypocretin and Melanin-Concentrating Hormone

Physiological Consequences of Hypocretin Activation

  • Physiological Characteristics of Hypocretin/Orexin Neurons
  • The NE System as a Target for Hypocretin Neurons: Implications for Regulation of Arousal
  • Hypocretin/Orexin Actions on Mesopontine Cholinergic Systems Controling Behavioral State
  • The Aminergic Systems and the Hypocretins
  • Effects of Hypocretin/Orexin on the Thalamocortical Activating System

Pharmacology of the Hypocretins and Drug Design

  • In Vivo Pharmacology of Orexin (Hypocretin) Receptors
  • Intracellular Signal Pathways Utilized by the Hypocretin/Orexin Receptors

The Hypocretins in Narcolepsy and Arousal

  • The Hypocretins and Narcolepsy: Pathophysiology and Diagnosis
  • An Approach to Determining the Functions of Hypocretin (Orexin)
  • Hypocretin in Neuropsychiatric Disorders
  • Hypocretin/Orexin and Sleep: Implications for the Pathophysiology of Human Narcolepsy
  • Modulation of Cortical Activity and Sleep-Wake States by Hypocretin/Orexin

The Hypocretins in Feeding and Energy Balance

  • Regulation of Hypocretin by Metabolic Signals

The Hypocretins in Addiction and Hyperarousal

  • Hypocretin and Brain Reward Function
  • Orexin/Hypocretin and Opioid Dependence
  • Dopamine - Hypocretin/Orexin Interactions: The Prefrontal Cortex and Schizophrenia
  • Hypocretin/Orexin in Stress and Arousal

Role of Hypocretins and Peripheral Systems

  • The Hypocretins/Orexins and the Hypothalamo-Pituitary-Adrenal Axis
  • Orexins (Hypocretins) in the Gut
  • Hypocretins in Endocrine Regulation
  • The Hypocretins in Cardiovascular Regulation

Index

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Hypocretins
Integrators of Physiological Functions
by Luis de Lecea

2005 439 pages $138.00 + shipping
Texas residents please add 6.75% sales tax

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