Features of Inhalation Toxicology, Second Edition:

• Focuses on the methods, measurements, and mechanisms of inhalation toxicology
• Includes coverage of the inhalation of biological agents
• Discusses the importance of developing chemical exposure numbers for emergency response planning purposes
• Highlights the use of new techniques such as toxicokinetic models, genomics, and proteomics
• Features coverage of in vivo studies and animal models, therapeutics, and chemicals
• Examines the data, methods, models, and guidelines used in health risk assessment to determine inhalation endpoints

Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. Emphasis is placed on the relationship between the respiratory system and toxicology of inhaled substances and the examination of methods and measurements for improving the understanding of the basic mechanisms of effects.

Contents

Inhalation Methods and Measurements

1. Inhalation Risk Assessment at the Environmental Protection Agency
2. The Development and Application of Acute Exposure Guideline Levels for Hazardous Substances
3. Emergency Response Planning Guidelines (ERPGs)
4. Directed Flow Aerosol Inhalation Exposure Systems: Application to Pathogens and Highly Toxic Agents
5. Low-Level Effects of VX Vapor Exposure on Pupil on Pupil Size and Cholinesterase Levels in Rats
6. Application of Intratracheal Instillation Exposure to the Etiological Determination of a Pulmonary Disease Outbreak: Nylon Flock as an Example
7. The Use of Large Animals in Inhalation Toxicology
8. Toxic Load Modeling
9. Inhalation Toxicology and Carcinogenicity Studies of the National Toxicology Program
10. Toxicology of Fire and Smoke

Inhalation Toxicology Methods

11. Toxicogenomics of Low-Level Nerve Agent Vapor Exposure
12. Respiratory Sensitization
13. Peripheral Chemosensory Irritation with Particular Reference to Respiratory Tract Exposure
14. Role of Cytokines in Pulmonary Inflammation and Fibrosis Induced by Inhaled Mineral Particles
15. Hormesis: Implications for Risk Assessment
16. Nasal Toxicology
17. Effects of Inhaled Toxicants on the Nose and Nasal Function
18. Toxicokinetics: Deposition, Absorption, Distribution, and Excretion
19. Mechanistic Determinants and Modeling of the Inhalation Pharmacokinetics of Volatile Organic Chemicals
20. Inhalation Toxicology of an Irritant Gas: Historical Perspectives, Current Research, and Case Studies of Phosgene Exposure
21. Inhalation Toxicology of Riot Control Agents
22. Chemical Warfare Agents and Nuclear Weapons
23. Inhalation Toxicology of Chromium Compounds
24. Safety Assessment of Therapeutic Agents Administered by the Inhalation Route
25. Nonclinical Pharmacology and Safety Studies of Insulin Administered to the Respiratory Tract

Inhalation Toxicology of Materials

26. Inhalation Toxicology of Alcohol/Gasoline Fuels: Current Status
27. Asbestos
28. The Inhalation Toxicity of Benzene
29. Carbon Monoxide
30. Experimental, Clinical, Occupational Toxicology and Forensic Aspects of Hydrogen Cyanide with Particular Reference to Vapor Exposure
31. The Pharmacology and Toxicology of Inhaled Dusts, Endotoxins, and Glucans
32. Fluorocarbon Alternatives: Methodologies for Special Studies and Results
33. Animal Models for Three Major Cigarette-Smoke-Induced Diseases
34. The Impact of Active and Passive Exposure to Cigarette Smoke on Maternal and Fetal Health

Inhalation Toxicology of Bioaerosols

35. Health Aspects of Bioaerosols
36. Emerging Biothreats: Natural and Deliberate
37. Toxicology Associated with Respiratory Exposures to Fungi (Molds)
38. Inhalation Toxicity of Botulinum Neurotoxin
39. Inhalation Ricin: Aerosol Procedures, Animal Toxicology, and Therapy
40. Toxicity, Mechanisms, Prophylaxis, and Therapy of Inhaled Biological Toxins

Index

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