Second Edition
by Robert Crichton

This book, which is the outcome of the collaboration between five specialist authors, coversthe fundamental concepts and applied aspects of iron biochemistry.

Exploring the chemistry, biology, biochemistry, physiology and medical aspects of iron in biological systems from microorganisms to man this essential title:

• Contains a NEW chapter dealing with the interactions of iron with other metals particularly copper and zinc
• Introduces illustrations and colour photos to make the basic concepts far clearer
• Includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc
• Provides additional anecdotes
• Incorporates an extensive and up-to-date bibliography
• Covers both fundamental and applied aspects
• And much more!

Contents

1. Solution Chemistry of Iron in Biological Media
   • Aqueous Solution Chemistry of Iron
   • Oxygen Free Radicals
   • Iron Hydrolysis - A Ubiquitous Phenomenon
   • Hydrolysis of Iron (III) in Acid Media - Formation of Polynuclear Species
   • Formation of Precipitates
   • Biomineralization

2. Importance of Iron for Biological Systems
   • Physical Techniques for the Study of Iron in Biological Systems
   • Haemoproteins
   • Iron-Sulfur Proteins
   • Other Iron-Containing Protein

3. Microbial Iron Uptake
   • Siderophores
   • Ferrous Iron Transport Systems
   • Iron Metabolism
   • Iron Regulation in Bacteria - the Fur Protein

4. Iron Uptake by Plants and Yeast
   • Iron Acquisition by Plants
   • Plant Ferritins
   • Iron Acquisition by Yeast
   • Intracellular Iron Metabolism
   • Iron Transport in Other Fungi

5. Cellular Iron Uptake in Mammals
   • Transferrins
   • Iron Uptake by Mammalian Cells - Uptake of Transferrin-bound Iron
   • Iron Uptake by Mammalian Cells-Uptake of Non-transferrin Bound Iron

6. Intracellular Iron Storage and Biolmineralization
   • Intracellular Iron Storage
   • Biomineralization

7. Intracellular Iron Metabolism and Cellular Iron Homeostasis
   • Intracellular Iron Metabolism
   • Metal Ion Homeostasis

8. Iron Absorption in Mammals with Particular Reference to Man
   • Iron Metabolism in Man: An Overview
   • Sources of Dietary Iron in Man and the Importance of Luminal Factors
   • Molecular Mechanisms of Mucosal Iron Absorption
   • Model of Iron Uptake and Regulation of Iron Homeostasis by the Enterocyte

9. Pathophysiology of Iron Deficiency and Iron Overload in Man
   • Introduction: Acquired and Genetic Disorders of Iron Metabolism
   • Body Iron Regulation
   • Iron Absorption in Disorders of Iron Metabolism
   • Iron Deficiency
   • Iron Overload

10. Iron and Oxidative Stress
    • Iron and Fenton Chemistry
    • Importance of Cytoprotection
    • Importance of Cell Type in Response to Oxidative Stress
    • Natural Resistance-associated Macrophage Protein (Nramp1)
    • Ageing of Cells
    • Cell Signalling and Iron
    • Apoptosis
    • Relationship Between NFKB and NO
    • How Does NO and H₂O₂ Affect the Iron Regulatory Proteins IRP-1 and IRP-2
    • Diseases in Which Increases in Iron may be Associated with Increased Oxidative Stress in the Cell
    • Diseases in Which Iron Plays and Important Role
    • Neurodegeneraative Diseases

11. Iron and Infection
    • Microbial Strategies to Overcome the Iron-withholding Imposed by the Host, and its Potential Clinical Consequences
    • Impact of Chronic Inflammation/Infection on Iron Metabolism
    • Impact of Iron Excess on Infection
    • Role of Iron-related Genes on the Risk and Outcome of Infection
    • Can Iron Depletion be Applied to Combat Infection?

12. Interactions Between Iron and Other Metals
    • Interactions Between Iron and Essential Metals
    • Iron and Toxic Metals

Index

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