Introduction to Proteomics provides a highly authoritative introduction to the promising and fast-advancing field of proteomics, examining the role proteomics plays in the study of biological systems in general and disease in particular. It helps readers understand the structure, function, and interactions of proteins and how this knowledge is used for identifying diseases and developing new drugs.

Topics covered include:

• Easily accessible overview of the principles of proteomics
• Coverage of real-world, cutting-edge medical applications, including personalized medicine
• Clear guidelines on how to operate the complex instrumentation involved in proteomics
• Discussion of the future of proteomics

Contents

Chapter 1: Historical Perspectives

• Introduction to Proteomics
• Proteome and Proteomics
• Genetics of Proteins
• Molecular Biology of Genes and Proteins
• Protein Chemistry Before Proteomics

Chapter 2: Proteomics-Relation to Genomics, Bioinformatics

• Genomics
• Bioinformatics and Computational Biology

Chapter 3: Methodology for Separation and Identification of Proteins and their Interations

• Separation of Proteins Via a Multidimensional Approach.
• Determination of the Primary Structure of Proteins.
• Determination of the 3D Structure of a Protein.
• Determination of the Amount of Proteins.
• Structural and Functional Proteomics

Chapter 4: Proteomics of Protein Modifications

• Phosphorylation and Phosphoproteomics
• Glycosylation and Glycoproteomics
• Ubiquitination and Ubiquitinomics
• Miscellaneous Modifications of Proteins

Chaper 5: Proteomics of Protein-Protein Interactions/Interactomes

• Protein—Protein Interactions (PPI) in Vivo
• Analysis of Protein Interactions in Vitro
• Analysis of Protein Interactions in Silico
• Synthetic Genetic Methods to Determine Protein Interactions
• Interactomes
• Evolution and Conservation of Interactomes
• Interactomes and the Complexity of Organisms: It is the Number of Interactomes that Matters in Understanding the Complexity of an Organism and not the Number of Genes
• Interaction of Proteins with Small Molecules

Chapter 6: Applications of Proteomics I: Proteomics, Human Disease, and Medicine

• Diseasome
• Medical Proteomics
• Clinical Proteomics
• Metaproteomics and Human Health
• Proteomics in Biotechnology and Industry of Drug Production
• Metaproteomics of Microbial Fermentation
• Beef Industry
• Bioterrorism and Biodefense

Chapter 7: Proteomics-Future Developments

• Technical Scope of Proteomics—Beyond Protein Identification
• Scientific Scope of Proteomics—Control of Epigenesis
• Medical Scope of Proteomics
• Proteomics, Energy Production, and Bioremediation
• Proteomics and Biodefense

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