Insulin Resistance
Insulin Action and Its Disturbances in Disease
edited by Sudhesh Kumar and Stephen O'Rahilly

Insulin Resistance reviews the normal biology of insulin action on glucose, lipids and proteins.

It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise.

Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined.

• Provides an expert review of the phenomenon of insulin resistance
• Brings together a host of recent research for the first time
• Written by leading experts in biological and clinical research

Contents

1. The Insulin Receptor and Downstream Signalling
2. Insulin-Mediated Regulation of Glucose Metabolism
3. Insulin Action on Lipid Metabolism
4. The Effect of Insulin on Protein Metabolism
5. Genetically Modified Mouse Models of Insulin Resistance
6. Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes
7. Central Regulation of Peripheral Glucose Metabolism
8. Relationship Between Fat Distribution and Insulin Resistance
9. PPARy and Glucose Homeostasis
10. Adipokines and Insulin Resistance
11. Dietary Factors and Insulin Resistance
12. Physical Activity and Insulin Resistance
13. Genetics of the Metabolic Syndrome
14. Insulin Resistance and Dyslipidaemia
15. Insulin Resistance, Hypertension and Endothelial Dysfunction
16. Insulin Resistance and Polycystic Ovary Syndrome
17. Syndromes of Severe Insulin Resistance (SSIRs)
18. Therapeutic Strategies for Insulin Resistance
19. Drug Therapy for Insulin Resistance – a Look at the Future

Index

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