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Pharmaceutical Drug Discovery
Reference from C.H.I.P.S.

Integrated Drug Discovery Technologies
edited by Houng-Yau Mei
and Anthony W. Czarnik

As the first of its kind, this up-to-the-minute reference provides a global overview of emerging drug discovery technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences.

Combining integration of contemporary mechanization with strategies in drug discovery, this volume features the most current advances that will afford better, faster, and more cost-effective means of design and screening.

To make the most of current and developing methods, Integrated Drug Discovery Technologies

  • presents the most promising science with the potential to revolutionize the drug discovery process
  • explains the rationale and developmental background behind evolving practices
  • highlights the impact of Information Technology on drug discovery
  • details information management, including strategies and infrastructure

With over 40 world-renowned experts, Integrated Drug Discovery Technologies is an invaluable resource for organic, analytical, medicinal, pharmaceutical, computational, protein, and peptide chemists and biochemists; pharmacists; pharmacologists; molecular and cell biologists; and upper-level undergraduate and graduate students in these disciplines.

Contents

Introduction

  1. The Motivation: A Top-Down View

Part I: From Gene to Screen

  1. Target Identification and Validation: Coupling Genotype to Phenotype
  2. Functional Genomics
  3. Integrated Proteomics Technologies
  4. Where Science Meets Silicon: Microfabrication Techniques and Their Scientific Applications
  5. SNP Scoring for Drug Discovery Applications
  6. Protein Display Chips
  7. Integrated Proteomics Technologies and In Vivo Validation of Molecular Targets

Part II: High-Throughput Screening

  1. High-Throughput Screening as a Discovery Resource
  2. Fluorescence Correlation Spectroscopy (FCS) and FCS-Related Confocal Fluorimetric Methods (FCS+ plus): Multiple Read-Out Options for Miniaturized Screening
  3. Homogeneous Time-Resolved Fluorescence
  4. ADME-Tox Screening in Drug Discovery
  5. Screening Lead Compounds in the Postgenomic Era: An Integrated Approach to Knowledge Building from Living Cells
  6. Miniaturization Technologies for High-Throughput Biology
  7. Data Management for High-Throughput Screening

Part III: High-Throughput Chemistry

  1. Combinatorial Chemistry: The History and the Basics
  2. New Synthetic Methodologies
  3. Supports for Solid-Phase Synthesis
  4. The NMR "Toolkit" for Compound Characterization
  5. Materials Management

Index

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Integrated Drug Discovery Technologies
edited by Houng-Yau Mei and Anthony W. Czarnik
2002 577 pages $188.95 + shipping

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