Drug Discovery book from C.H.I.P.S.

Integrated Strategies for Drug Discovery Using Mass Spectrometry
edited by
Mike S. Lee

Integrated Strategies for Drug Discovery Using Mass Spectrometry provides a thorough review of current analytical approaches, industry practices, and strategies in drug discovery.

The topics represent current industry benchmarks in specific drug discovery activities that deal with proteomics, biomarker discovery, metabonomic approaches for toxicity screening, lead identification, compound libraries, quantitative bioanalytical support, biotransformation, reactive metabolite characterization, lead optimization, pharmaceutical property profiling, sample preparation strategies, and automation.

Integrated Strategies for Drug Discovery Using Mass Spectrometry:

  • Clearly explains how drug discovery and mass spectrometry are interconnected
  • Discusses the uses and limitations of various types of mass spectrometry in various aspects of drug discovery
  • Prominently features analytical applications that require trace-mixture analysis
  • Provides industry applications and real-world examples
  • Shares historical background information on various techniques to aid in the understanding of how and why new methods are now being employed to analyze samples


  1. Miniaturized Formats for Efficient Liquid Chromatography Mass Spectrometry-Based Proteomics and Therapeutic Development
  2. Mass-Spectrometry-Based Drug Screening Assays for Early Phases in Drug Discovery
  3. ESI-FTICR as a High Throughput Drug Discovery Platform
  4. Mass Spectrometry- Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery
  5. Metabonomic Applications in Toxicity Screening and Disease Diagnosis
  6. The Central Role of Mass Spectrometry in Natural Products Discovery
  7. Application of Mass Spectrometry to Compound Library Generation, Analysis, and Management
  8. A Combinatorial Process for Drug Discovery
  9. Application of Technological Advances in Biotransformation Studies
  10. Applications of Mass Spectrometry for the Characterization of Reactive Metabolites of Drugs in Discovery
  11. Advances in High Throughput Quantitative Drug Discovery Bioanalysis
  12. New Strategies for the Implementation and Support of Bioanalysis in a Drug Metabolism Environment
  13. An Integrated LC-MS Strategy for Preclinical Candidate Optimization
  14. New Approaches for Method Development and Purification in Lead Optimization
  15. High Throughput Metabolic and Physicochemical Property Analysis: Strategies and Tactics for Impact on Drug Discovery Success
  16. Organ Perfusion and Mass Spectrometry
  17. Sample Preparation for Drug Discovery Bioanalysis
  18. Automation

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Integrated Strategies for Drug Discovery
Using Mass Spectrometry

edited by Mike S. Lee

2005 550 pages $129.00 + shipping
Texas residents please add 6.75 % sales tax

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