Intracellular Signaling Mechanisms for Neuritogenesis presents novel, distinct, but highly related aspects of the intracellular mechanisms required for the formation of a functional neurite, which include cytoskeletal organization, membrane traffic, and signal transduction.

In particular, the book addresses the importance of the integration among distinct aspects of the cell biology of developing neurons involved in neurite extension. The aim of the book is to present this topic to the general readership of neurobiologists and molecular and cellular biologists to further stimulate the interest into this exciting section of neurobiology. It represents a reference for researchers directly involved in the study of neuronal development, and a textbook for PhD courses in molecular neurobiology.

Contents

1. Adhesion-induced intracellular mechanisms of neurite elongation
2. Regulation of growth cone initiation and actin dynamics by ADF/cofilin
3. Role of microtubules and MAPs during neuritogenesis
4. Small GTPases: mechanisms linking membrane traffic to cytoskeleton during neuritogenesis
5. Exocytic mechanisms for axonal and dendritic growth
6. Role of the Golgi apparatus during axon formation
7. Focal adhesion kinase in neuritogenesis.
8. Regulation of neuronal morphogenesis by Abl family kinases
9. Membrane glycolipids in neurotrophin receptor-mediated signaling
10. Wnt Signaling in Neurite Development
11. The Role of CRMP-2 in Neuronal Polarization
12. Regulation of axon branching
13. A comparative analysis of neural crest cell and axonal growth cone dynamics and behavior
14. Mechanisms of Axon regeneration

Index

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