Introduction to Mass Spectrometry provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations.

Introduction to Mass Spectrometry features:

• the fundamentals as well as recent advance in this topic
• providing need-to-know information for researchers in many disciplines including pharmaceutical
• environmental and biomedical analysis who are utilizing mass spectrometry

Contents

1. Introduction

1. What is Mass Spectrometry
2. History
3. Applications
4. The Data of Mass Spectrometry and Its Presentation
5. Definition of Terms

2. The Mass Spectrometer

1. Ion Guides
2. Types of m/z Analyzers
3. Calibration of the m/z Scale
4. Ion Detection
5. Vacuum Systems

3. Mass Spectrometry/Mass Spectrometry

1. Ion Dissociation
2. Instrumentation for MS/MS
3. Specialized Techniques and Applications
4. Identification of Unknowns from CAD Data

4. Inlet Systems

1. Batch Inlets
2. Continuous Inlets
3. Ionization Inlet Systems
4. Speciality Interfaces

5. Strategies for Data Interpretation (Other than Fragmentation)

1. Some Important Definitions
2. The Possible Information That Can be Obtained from the Mass Spectrum
3. Elemental Composition of an Ion and the Ratios of Its Isotope Peaks
4. Identifying the Molecular Mass of an Analyte
5. Recognition of Spurious Peaks in the Mass Spectrum
6. Obtaining Structural Information from Mass Spectra

6. Electron Ionization

1. Ionization Process
2. Strategy for Data Interpretation
3. Types of Fragmentation Pathways
4. Representative Fragmentations (Spectra) of Classes of Compound
5. Library Search
6. Summary of Interpretation of EI Mass Spectra

7. Chemical Ionization

1. Description of the Chemical Ionization Source
2. Production of Reagent Ions from Various Reagent Gases
3. Positive-Ion Formation Under CI
4. Negative-Ion Formation under CI
5. Data Interpretation and Systematic Studies of CI
6. Ionization by Charge Exchange
7. Desorption Chemical Ionization
8. General Applications

8. Electrospray Ionization

1. Operating Principles
2. Appearance of ESI Mass Spectra and Data Interpretation
3. ESI with High Mass Resolving Power
4. Implementations of Electrospray
5. Effect of Composition and Flowrate of Analyte Solution
6. Special Applications
7. General Applications

9. MALDI

1. Historical Perspective and Introduction
2. Operating Principles
3. Sample Handling
4. Special Instrumental Techniques
5. Representative Applications

10. GC/MS

1. Introduction to GC
2. Sample Handling
3. Instrument Requirements for GC/MS
4. Operational Considerations
5. Sources of Error
6. Representative Applications of GC/MS

11. Liquid Chromatography/Mass Spectrometry

1. Historical Milestones in the Development of the Interface
2. Currently Viable Versions of the Interface
3. Operational Considerations (Special Operation of LC under MS Conditions)
4. Applications

12. Analysis of Proteins and other Biopolymers

1. Proteins
2. Oligonucleotides
3. Carbohydrates

Index

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