edited by
Michael E. Burczynski

Features:

• Presents a clear introduction to expression profiling and large scale data analysis applicable to any field of research
• Explains the complex clustering algorithms required for expression profiling analyses
• Includes stunning images involved in microarray analysis of large-scale data sets
• Provides additional information and cites specific examples that illustrate the principles of toxicogenomics
• Describes toxicogenomic findings in two of the main model systems employed in toxicological research today
• Equally explores concepts and applications in both mechanistic and predictive toxicogenomics

Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies.

An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

Contents

1. Fundamentals of Expression Profiling Analysis
   • Preparation and Utilization of Microarrays
   • Comparative Studies Using cDNA versus Oligonucleotide Arrays
   • Quality Control of Expression Profiling Data
   • An Introduction to Cluster Analysis

2. Expression Profiling and Toxicology: The Advent of Toxicogenomics
   • Transcriptional Profiling in Toxicology

3. Model Systems in Toxicogenomic Studies
   • Microarrays in Drug Metabolism and Toxicology: Rat Liver Responses to Prototypical CYP Inducers
   • Characterization of Hepatocytes and Their Use as a Model System in Toxicogenomics

4. Mechanistic Toxicogenomics
   • Molecular Signatures of Dioxin Toxicity Toxicogenomic Dissection of the Antioxidant Response
   • An Overview of Mechanistic Toxicogenomic Studies

5. Predictive Toxicogenomics
   • Gene Expression Profile Databases in Toxicity Testing
   • Predictive Toxicogenomics
   • Unsupervised Hierarchical Clustering of Toxicants
   • Toxicogenomic Analysis in Clinical Phamacogenomic Studies

6. The Future of Toxicogenomics
   • The Future of Toxicogenomics

Glossary
Appendix
Index

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