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In Vivo NMR Spectroscopy
Principles and Techniques
Second edition
by Robin A. de Graaf

In Vivo NMR Spectroscopy is a unique book in the field of in vivo NMR covering in detail the technical and biophysical aspects of the technique.

The contents of the book are appropriate to both beginners and experienced users of in vivo NMR spectroscopy. The new edition is focussed on bringing the reader practical insights and advice, but is also geared towards use as a study aid and in NMR courses.

Recent advances in NMR spectroscopy, like high field NMR, hyperpolarized NMR and new localization and editing techniques have been included. An extensive and updated treatment of radiofrequency pulses is given, together with several tables and recipes for their generation.


1 Basic Principles

  • Classical Description
  • Quantum Mechanical Description
  • Macroscopic Magnetization
  • Excitation
  • Bloch Equations
  • Fourier Transform NMR
  • Chemical Shift
  • Digital Fourier Transform NMR
  • Spin–spin Coupling
  • T1 Relaxation
  • T2 Relaxation and Spin-echoes

2 In Vivo NMR Spectroscopy – Static Aspects

  • Proton NMR Spectroscopy
  • Phosphorus-31 NMR Spectroscopy
  • Carbon-13 NMR Spectroscopy
  • Sodium-23 and Potassium-39 NMR Spectroscopy
  • Fluorine-19 NMR Spectroscopy

3 In Vivo NMR Spectroscopy – Dynamic Aspects

  • Relaxation
  • Magnetization Transfer
  • Diffusion
  • Dynamic Carbon-13 NMR Spectroscopy
  • Hyperpolarization

4 Magnetic Resonance Imaging

  • Magnetic Field Gradients
  • Slice Selection
  • Frequency Encoding
  • Phase Encoding
  • Spatial Frequency Space
  • Fast MRI Sequences
  • Contrast in MRI
  • Parallel MRI

5 Radiofrequency Pulses

  • Square RF Pulses
  • Selective RF Pulses
  • Pulse Optimization
  • DANTE RF Pulses
  • Composite RF Pulses
  • Adiabatic RF Pulses
  • Pulse Imperfections and Relaxation
  • Power Deposition
  • Multidimensional RF Pulses
  • Spectral–spatial RF Pulses

6 Single Volume Localization and Water Suppression

  • Single Volume Localization
  • Water Suppression

7 Spectroscopic Imaging and Multivolume Localization

  • Principles of Spectroscopic Imaging
  • Spatial Resolution in MRSI
  • Temporal Resolution in MRSI
  • Lipid Suppression
  • Spectroscopic Imaging Processing and Display
  • Multivolume Localization

8 Spectral Editing and Two-dimensional NMR

  • Scalar Evolution
  • J-difference Editing
  • Practical Considerations of J-difference Editing
  • Multiple Quantum Coherence Editing
  • Heteronuclear Spectral Editing
  • Polarization Transfer – INEPT and DEPT
  • Sensitivity
  • Broadband Decoupling
  • Two-dimensional NMR Spectroscopy

9 Spectral Quantification

  • Data Acquisition
  • Data Pre-processing
  • Data Quantification
  • Data Calibration

10 Hardware

  • Magnets
  • Magnetic Field Homogeneity
  • Magnetic Field Gradients
  • Radiofrequency Coils
  • Radiofrequency Coil Types
  • Complete MR System


  • Matrix Calculations
  • Trigonometric Equations
  • Fourier Transformation
  • Product Operator Formalism


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In Vivo NMR Spectroscopy
Principles and Techniques
Second edition
by Robin A. de Graaf

2008 • 570 pages • $108.00 + shipping
Texas residents please add 6.75 % sales tax

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