The Kidney and Hypertension in Diabetes Mellitus covers all aspects of renal involvement in diabetes and incorporates information from important publications and new trials conducted during the last three years.

The Kidney and Hypertension in Diabetes Mellitus focuses on pressure-induced and metabolic related aberration in relation to genetic abnormalities, and also changes developing in fetal life.

New chapters explore exercise, lipidemia, and retinopathy in diabetic renal disease and new data are presented regarding structural changes in NIDDM-patients and the comparison of diabetic and non-diabetic renal disease.

The Kidney and Hypertension in Diabetes Mellitus covers new guidelines and definitions in type 2 diabetes, management of end-stage renal failure, and demographic trends in the patient population.

Other topics include diabetic nephropathy, glycemic control, and early treatment in normotensive patients with microalbuminuria with ACE-inhibitors.

Contents:

1. Rationale for early screening for diabetic renal disease
2. Pressure-induced and metabolic alterations in the glomerulus : cytoskeletal changes
3. The Steno hypothesis for cardiovascular and renal disease revisited
4. Microalbuminuria and cardiovascular disease
5. The heart in diabetes : results of trials
6. Microalbuminuria and GFR in type 1 and type 2 diabetes
7. Serum creatinine and other measures of GFR in diabetes
8. Familiai factors in diabetic nephropathy
9. Genetics and diabetic nephropathy
10. Low birth weight and diabetic nephropathy
11. Effects of insulin on the cardiovascular system and the kidney
12. Value of screening for microalbuminuria in people with diabetes as well as in the general population
13. Dysfunction of the vascular endothelium and the development of renal and vascular complications in diabetes
14. Pathogenesis and management of bacterial urinary tract infections in adult patients with diabetes mellitus
15. Pathology of the kidney in diabetes mellitus
16. Renal structural changes in patients with type 1 diabetes and microalbuminuria
17. Renal structure in type 2 diabetes
18. Nephropathy in type 2 diabetic patients, predictors of outcome
19. Advanced glycation end-products and diabetic renal disease
20. Protein kinase C activation and its inhibition for the treatment of diabetic renal pathologies
21. Biochemical aspects of diabetic nephropathy
22. Pathogenesis of diabetic glomerulopathy : the role of glomerular hemodynamic factors
23. The emerging role of growth factor hormone (GH) and vascular endothelial growth factor (VEGF) in diabetic kidney disease
24. Transforming growth factor-[beta] and other cytokines in experimental and human diabetic nephropathy
25. Blood pressure elevation in diabetes : the results from 24-h ambulatory blood pressure recordings
26. Microalbuminuria in young patients with type 1 diabetes
27. Early renal hyperfunction and hypertrophy in IDDM, including comments on early intervention
28. Autoregulation of glomerular filtration rate in patients with diabetes
29. The role of renal biopsy in the clinic
30. Inhibition of the renin angiotensin aldosterone system, with particular reference to the dual blockade principle
31. The concept of incipient diabetic nephropathy and the effect of early antihypertensive intervention
32. The role of proteinuria in the diagnosis and treatment of type 2 diabetes
33. Antihypertensive treatment in type 2 diabetes, with special reference to abnormal albuminuria : a focus on the new trials
34. Blood pressure lowering treatment and the prevention of stroke in the diabetic patient
35. Non-glycaemic intervention in diabetic nephropathy : the role of dietary protein and salt intake
36. Diabetic nephropathy and pregnancy
37. Evolution worldwide of renal replacement therapy in diabetes
38. Hemodialysis and CAPD in type 1 and type 2 diabetic patients with endstage renal failure
39. Renal and pancreas transplants in diabetes
40. Combination therapy for hypertension and renal disease in diabetes
41. Microalbuminuria in essential hypertension : cardiovascular and renal implications
42. A comparison of progression in diabetic and non-diabetic renal disease : similarity of progression promoters
43. Scientific basis for new guidelines for the treatment of hypertension in type 2 diabetes
44. Regulatory considerations in the development of therapies for diabetic nephropathy and related conditions
45. Diabetes, hypertension, and kidney disease in the Pima Indians
46. The development and progression of clinical nephropathy in white patients with type 2 diabetes
47. Microalbuminuria, blood pressure and diabetic renal disease : origin and development of ideas