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Kindling 6
by Michael E. Corcoran

Kindling 6 provides valuable summaries of the ongoing research on seizure development, with an emphasis on mechanisms, consequences, and potential treatments that might offset epileptogenesis.


Pathogenesis of Kindling

  • Developmental Temporal Lobe Epilepsy in Amygdala Kindled Kittens: An Update
  • Prenatal Betamethasone Exposure Suppresses Kindling Epileptogenesis in Immature Rats
  • Development of Kindling in Immature Fast and Slow Kindling Rats
  • Neonatal Heat-Induced Convulsions Affect Behaviours in Neonatal, Juvenile and Adult Rats
  • Experimental Absence Versus Amygdaloid Kindling
  • Pentylenetetrazol-Induced Kindling as a Model of Absence and Convulsive Forms of Epilepsy


  • Sodium Current Properties in Different Models of Epilepsy
  • Kindling the Gabaergic Phenotype of the Glutamatergic Granule Cells
  • Hippocampal Kindling and GABAB Receptor Functions
  • Altered Interaction Between the Entorhinal Cortex and Hippocampus in Amygdala Kindled Rats

Anatomy, Morphology, and Neural Circuitry

  • Nature and Consequences of Seizures Originating in the Brainstem
  • Involvement in the Claustrum and Ventromedial Thalamus in Epileptogenesis
  • From Ultrastructure to Networks: Kindling-Induced Changes in Neocortex
  • Kindling as a Tool for Studying the Role of Subcortical Structures in Limbic Seizures
  • Kindling, Epilepsy, and the Plasticity of Network Synchronization

Genes, Species, and Strains

  • Electrophysiological and Anatomical Differences, Behavioral Comorbidities and Gene Expression in Fast and Slow Kindling Rat Strains
  • Gene Expression Changes in Kindling
  • A Proteomic Approach to the Molecular Analysis of Kindling

Synaptic Pharmacology and Neurochemistry

  • Amygdala Metabotropic Glutamate Receptors and Kindling
  • Induction of B1 Bradykinin Receptors in the Kindled Brain
  • Galanin and Kindling
  • Kindling, Neurotrophins and Axon-Guidance Factors
  • Conditional Deletion of TRKB Prevents Epileptogenesis in the Kindling Model
  • Neuropeptide Y and its Receptors in Kindling Epileptogenesis

Behavioral Consequences of Kindling

  • Contribution of Pre Kindling Affective State to Hemispheric Differences in the Effects on Anxiety of Basolateral Amygdala Kindling
  • Effects of Kindling on Spatial Memory: Characteristics and Mechanisms
  • A Potential Role for the Hippocampus in the Expression of Kindling-Induced Fear
  • Does Inadvertent Conditioning Contribute to the Major Features of Kindling?

Drugs and Interventions Against Kindling

  • Contingent Tolerance and Cross Tolerance to Anticonvulsant Effects in Amygdala-Kindled Seizures: Mechanistic and Clinical Implications
  • Mechanisms of Pharmacoresistance in the Phenytoin-Resistant Kindled Wistar Rat
  • Development of New Anticonvulsants Using the Kindling Model
  • Cannabinoids and Kindling
  • Low Frequency Sine Wave Stimulation Decreases the Incidence of Kindled Seizures

Clinical Relevence of Kindling for our Understanding of Epilepsy in Patients

  • Predisposed Susceptibility in Primate Epileptogenesis and Anti-Epileptogenesis
  • Natural History of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: How Does Kindling Compare with Other Commonly Used Animal Models
  • Clinical Evidence of Epilepsy-Related Plasticity
  • Pathological Sensitization of the Dopamine System in Experimental Epileptogenesis: Implication for the Mechanism of Epileptic Psychosis


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Kindling 6
by Michael E. Corcoran
2005 • 415 pages • $174.00 + shipping
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