Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. This is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs.

LC/MS Applications in Drug Development book is the premier reference on the cutting-edge technology driving new drug development. It is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.

Features:

• Proteomics
• Glycoprotein Mapping
• Natural Products Dereplication
• Lead Identification Screening
• Open-Access LC/MS
• In Vivo Drug Screening
• In Vitro Drug Screening

LC/MS Applications in Drug Development is written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce.

Contents

1. Introduction
2. Drug Development Overview
3. Accelerated Drug Development
4. LC/MS Development
5. Strategies
6. LC/MS Applications
7. Future Applications and Prospects
8. Perspectives on the Future Growth of LC/MS
9. Conclusions

Glossary
References
Index

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