LC/MS
A Practical User's Guide
by Marvin C. McMaster

LC/MS: A Practical User's Guide presents technical data in an easily understood format, explains how to keep LC/MS systems up and running, and shows how to interpret and quantitate the mass spectral data using proven spectral databases, without devolving into a university-style course curriculum.

• Takes a purely practical approach to using and maintaining LC/MS systems
• Introduces the reader to quadrupole and ion trap analyzers, which make up the bulk of the equipment being sold for laboratory and analytical studies
• Presents technical data in an illustrated, easily understood format
• Explains how to keep systems up and running
• Shows how to interpret and quantitate mass spectral data using proven spectral databases

Contents

1. Introduction to LC/MS
2. The HPLC System
3. The HPLC Column and Separation Modes
4. HPLC and Column Maintenance
5. Sample Preparation and Separations Development
6. LC/MS Interfaces
7. LC/MS Overview
8. The Mass Analyzers
9. Mass Spectrometer Maintence
10. Application Areas for LC/MS
11. Trace Analysis and LC/MS/MS
12. Drug Discovery and Benchtop LC/MS
13. Proteomics: LC/MALDI/TOF and MS/MS Libraries
14. The Future of LC/MS

Appendices

• LC/MS Frequently Asked Questions
• Solvents and Volatile Buffers for LC/MS
• A Guide to Structure Interpretation
• A Glossary of LC/MS Terms
• LC/MS Selective Reading List

Index

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