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Lead Generation Pharmaceutical Book
from C.H.I.P.S.

Lead Generation Approaches in Drug Discovery
edited by Zoran Rankovic

This book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including:

  • The evolution of the lead discovery process, key concepts, current challenges, and future directions
  • Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process
  • Knowledge-based in silico or "virtual" screening
  • Theory and practice of the fragment-based approach to lead discovery
  • The opportunities and challenges presented by multi-target drug discovery (MTDD)
  • De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules
  • The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space
  • Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery
  • The utility of parallel synthesis and purification in lead discovery

Contents

  1. Lead Discovery: The Process
  2. High Throughput Screening Approach to Lead Discovery
  3. In Silico Screening
  4. Fragment-Based Lead Discovery
  5. Design of Multitarget Ligands
  6. De novo Drug Design
  7. Role of Natural Products in Drug Discovery
  8. Early Screening for ADMET Properties
  9. Role of Chemistry in Lead Discovery

Index

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Lead Generation Approaches in Drug Discovery
edited by Zoran Rankovic
2010 • 295 pages • $98.95 + shipping
Texas residents please add 6.75 % sales tax

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