edited by Günter Müller
and Stefan Petry

Providing drug developers with a firm foundation for lipase-centered drug design, the editors of this volume have assembled experts from different scientific disciplines to create a comprehensive handbook for medicinal chemists, structural biologists, biochemists and physiologists interested in lipases.

Contents

1. Purification of Lipase
2. Phospholipase A1: Structures, Physiological and Pathophysiological Roles in Mammals
3. Rational Design of a Liposomal Drug Delivery System Based on Biophysical Studies of Phospholipase A2 Activity
4. Phospholipase D
5. Sphingomyelinases and their Interaction with Membrane Lipids
6. Glycosyl-Phosphatidylinositol Cleavage Products in Signal Transduction
7. HTS of Hormone-sensitive Lipase and Subsequent Computer-assisted Compound Optimization
8. Endothelial Lipase: a Novel Drug Target for HDL and Atherosclerosis?
9. Digestive Lipases Inhibition: an in vitro Study.
10. Physiology of Gastrointestinal Lipolysis and Therapeutical Use of Lipases and Digestive Lipase Inhibitors
11. Physiological and Pharmacological Regulation of Triacylglycerol Storage and Mobilization

Index

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