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Drug Design Handbook from C.H.I.P.S.

Lipases
and Phospholipases
in Drug Development:

From Biochemistry to Molecular Pharmacology

edited by Günter Müller
and Stefan Petry


Providing drug developers with a firm foundation for lipase-centered drug design, the editors of this volume have assembled experts from different scientific disciplines to create a comprehensive handbook for medicinal chemists, structural biologists, biochemists and physiologists interested in lipases.

Contents

  1. Purification of Lipase
  2. Phospholipase A1: Structures, Physiological and Pathophysiological Roles in Mammals
  3. Rational Design of a Liposomal Drug Delivery System Based on Biophysical Studies of Phospholipase A2 Activity
  4. Phospholipase D
  5. Sphingomyelinases and their Interaction with Membrane Lipids
  6. Glycosyl-Phosphatidylinositol Cleavage Products in Signal Transduction
  7. HTS of Hormone-sensitive Lipase and Subsequent Computer-assisted Compound Optimization
  8. Endothelial Lipase: a Novel Drug Target for HDL and Atherosclerosis?
  9. Digestive Lipases Inhibition: an in vitro Study.
  10. Physiology of Gastrointestinal Lipolysis and Therapeutical Use of Lipases and Digestive Lipase Inhibitors
  11. Physiological and Pharmacological Regulation of Triacylglycerol Storage and Mobilization

Index

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Lipases and Phospholipases in Drug Development:
From Biochemistry to Molecular Pharmacology
edited by Günter Müller and Stefan Petry

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