Liquid Chromatography—Mass Spectrometry:
An Introduction
by Bob Ardrey

Features:

• The provision of many discussion and self-assessment questions throughout the text, thus providing opportunities for testing the reader's understanding of the subject matter

• Presented in the AnTS (open learning/distance learning) style, it is ideal for use as both a self-study guide and as the basis of a taught course

• A comprehensive bibliography, including books, papers/articles in journals and on websites, along with specific references for the individual chapters, to guide the reader to more specialised texts and original sources

This book provides coverage of all of the major analytical techniques and their application in the most important areas of physical, life and materials science. The reader's understanding of the material is constantly evaluated by the use of self-assessment and discussion questions.

The topics covered in this text include the following:

• The basic principles of liquid chromatography and mass spectrometry

• The limitations of the component techniques when used in isolation, and how a combination of the two allows these to be overcome

• Descriptions of the various approaches, including thermospray, electrospray and atmospheric pressure chemical ionization, which are used to interface the two techniques, along with the advantages and disadvantages of each system

• Illustrative examples of the applications of LC-MS, including the molecular weight and structure determinations of both biopolymers and low-molecular-compounds, along with the development of quantitative methods

Written with a student audience in mind, this text will provide an invaluable introduction to this increasingly important analytical tandem technique.

Contents

Abbreviations, Acronyms, and Symbols

1. Introduction
2. Liquid Chromatography
3. Mass Spectrometry
4. Interface Technology
5. Applications of High Performance Liquid Chromatography—Mass Spectrometry

Responses to Self-Assessment Questions
Glossary of Terms
SI Units and Physical Constants
Periodic Table
Index

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