Lung Surfactant Function and Disorder analyzes lung surfactant function from the aspects of molecular biology, biophysics, membrane science, and surface and interface analysis.

Features:

• Addresses standard, novel, and controversial issues and alternative views of surfactant function
• Supplies comprehensive listings of references through 2004
• Discusses methods used to determine the molecular dynamics and nanoscale, supramolecular, and single-molecular organization of membranous systems as applied to the lung surfactnat
• Contains diverse experimental protocols of methods such as NMR, AFM, TOF-SIMS, mass spectrometry, single-channel recording, computer modeling, genetic-knockout, and colloidal and surface analysis
• Describes the structure-function relationship of the lung surfactant in normal and disease or (dys)functional states
• Comprehensively assesses techniques for the study of membranes, surfactant and bio-colloidal surfaces and interfaces including Langmuir-Blodgett films, bubble imaging, atomic force microscopy, TOF-SIMS, and Raman and FTIR spectroscopy
• Studies the physiology and pathology of molecular mechanisms at the lung gas-water interface

Contents

• Composition, Structure, and Function
• Lung Surfactant Phospholipid Molecular Species in Health and Disease
• New Insights into Thermal Dynamics of the Surfactant System from Warm and Cold Animals
• Molecular and Functional Properties of Surfactant Protein A
• Receptors and Ligands for Collectin Surfactant Proteins A and D
• Structure-Function Relationships of Hydrophobic Proteins SP-B and SP-C in Pulmonary Surfactant
• Biophysics and Molecular Mechanisms
• Chain Dancing, Super-Cool Surfactant, and Heavy-Breathing: Rafts, Membranes and Phase Transitions
• The Basis of Low Surface Tension in the Lungs
• Surfactant and Airway Liquid Flows
• Lung Surfactants: A Molecular Perspective from Computation
• Analysis of Surface Topology and Chemical Composition of Microstructures Formed in Planar Surfactant Films Under Compression
• SP-B Peptides: Synthesis, Structure, and Surface Activity
• Structure and Function of the Molecular Film of Pulmonary Surfactant at the Air-Alveolar Interface: The Role of SP-C
• Analysis of SP-C Function in Transgenic and Gene Targeted Mice
• Alternative Functions of SP-B and SP-C
• Dysfunction and Disease
• The Physiological Significance of a Dysfunctional Lung Surfactant
• Pulmonary Surfactant in Asthma and Allergy
• Surfactant Treatment for Inflammatory Lung Disease
• Alteration of Alveolar Surfactant Function by Reactive Oxygen Species
• Novel Surfactant Therapy for Developing Countries

Index

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