Lung and Heart-Lung Transplantation focuses on cumulative data from the International Registry with data on outcomes associated with LT and HLT worldwide.

Features:

• Contains chapters on immune tolerance, regulatory T cells, dendritic cells, and animal models for a clear framework to understand the pitfalls inherent in clinical LT
• Considers immunologic issues associated with lung transplantation such as acute and chronic allograft rejection
• Discusses specific parameters and physiologic, radiographic, and clinical criteria for various disease states that influence practitioners to refer patients for lung transplantation
• Details the impact of panresistant Pseudomonas aeruginosa, Burkoholderia cepacea, aspergillus, and atypical mycobacteria on morbidity and mortality
• Provides a global perspective on the current and future role of LT

Contents

Clinical Aspects

• Historical Overview of Lung and Heart-Lung Transplantation

Immunology of Transplantation: Basic Science

• Basic Immunologic Concepts Involved in Lung Transplantation
• Allogeneic Recognition
• Tolerance
• Immunological Techniques for Assessing Alloreactivity in Potential Organ Recipients

Clincal Aspects

• COPD and ?1-Antitrypsin Deficiency Emphysema
• Cystic Fibrosis and Bronchiectasis
• Pulmonary Hypertension
• Lung Transplantation for Interstitial and Cystic Lung Diseases
• Pediatric Lung Transplantation
• Living Lobar Lung Transplantation
• Controversies in Transplantation
• Hear-Lung Transplantation

Organ Allocation and Donor Availability

• Allocation of Donor Organs
• European Experience
• Australian Experience
• Lung Preservation Techniques
• Operative Techniques Utilized in Lung Transplantation

Immunosuppresion: Action, Efficacy, Drug Interactions and Toxicities

• Cyclosporine, Tacrolimus, Sirolimus, Azathioprine, Mycophenolar, Mofetil, Corticosteroids
• Lympholytic Agents
• Novel and Future Approaches to Immunosuppression

Complications in Lung Transplantation

• Early Graft Dysfunction and Primary Graft Failure Following Lung Transplantation: Clinical Features, Recognition, and Treatment
• Early Graft Dysfunction Following Lung Transplantation: Pathogenesis and Impact of Late Allograft Function
• Airway Complications

Infectious Complications

• Viral Infections Complication Lung and Solid Organ Transplantation
• Invasive Fungal Infections Complicating Lung and Solid Organ Transplantation
• Bacterial Infections

Lung Allograft Rejection

• Clinical Features of Acute Rejection: Incidence, Clinical Features, Management
• Histology of Lung or Heart-Lung Allograft Rejection
• Animal Models of Acute and Chronic Rejection

Chronic Allograft Rejection

• Obliterative Bronchiolitis: Incidence, Clinical Features, Histology, Diagnosis, and Treatment
• Pathogenesis of Bronchiolitis Obliterans Syndrome
• Pulmonary Physiology Post-Transplant
• Role of Surveillance Bronchoscopy
• Thoracic Imaging Post Lung Transplant

Long-Term Complications of Lung Transplantation

• Cardiac, Renal, Hypertension, Lipids, Metabolic, Osteoporosis
• Neoplasia Following Transplantation

Index

click here to see books • videos • cd-roms of related interest