edited by David T. Rossi
and Michael W. Sinz

This state-of-the-art reference summarizes the theory, instrumentation, and application of mass spectrometry and atmospheric pressure ionization to screen, evaluate, and improve the performance and quality of drug candidates—offering current techniques in pharmaceutics and pharmacokinetics for increased quantities of new pharmaceutical compounds.

Providing time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, Mass Spectrometry in Drug Discovery covers:

• recent advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing
• cassette dosing in drug discovery
• the utilization of liquid chromatography/mass spectrometry (LC/MS) in chemical library characterization, combinatorial chemistry, drug transport, and in vivo microdialysis
• reliable methods of sample preparation and handling
• novel strategies to determine and characterize metabolite structures
• the impact of absorption, distribution, metabolism, and elimination properties on drug discovery
• the latest research using stable-labeled compounds

Demonstrating the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents, Mass Spectrometry in Drug Discovery is an invaluable source for spectrometrists; pharmacologists; analytical, medicinal, and organic chemists and biochemists; biotechnologists; pharmaceutical scientists; toxicologists; and upper-level undergraduate and graduate students in these disciplines.

Contents

1. Introduction
   1. The Demand for Drug Discovery Today
   2. The Impact of Atmospheric Pressure Ionization

2. Instrumentation
   3. A Mass Spectrometry Primer

3. Experimental Strategies
   4. Ion Chemistry and Fragmentation
   5. The LC/MS Experiment
   6. Sample Preparation and Handling for LC/MS in Drug Discovery

4. Applications
   7. Mass Spectrometry in Combinatorial Chemistry
   8. Drug Hydrophobicity and Transport
   9. The Mass Spectrometer in Drug Metabolism
   10. Mass Spectrometry-Assisted Applications of Stable-Labeled Compounds in Pharmacokinetic and Drug Metabolism Studies
   11. Cassette Dosing in Drug Discovery
   12. Applications of Microdialysis/Mass Spectrometry to Drug Discovery
   13. Future Directions for Mass Spectrometry in Drug Discovery

Index

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ORDER NOW Mass Spectrometry in Drug Discovery edited by David T. Rossi and Michael W. Sinz 2002 • 420 pages • $178.95 + shipping Texas residents please add 7 % sales tax