Mass Spectrometry in Sports Drug Testing examines both the principles of sports drug testing and the use of mass spectrometry techniques and mass spectral data to detect, identify, and characterize hundreds of known and unknown drugs that athletes may use to enhance their performance.

The author provides a detailed overview of the mass spectrometry of numerous classes of therapeutics and agents, various analyzers to detect low- and high-molecular weight drugs, as well as techniques to discriminate between endogenously produced and synthetically derived compounds.

Contents

Part 1: History of Sports Drug Testing

• Historical Attempts of Artificial Performance Enhancement
• Background and Rationale of Doping Controls
• Early Detection Methods: Possibilities and Limitations of Assays Without Mass Spectrometry
• Introduction of Mass Spectrometry to Doping Control Analysis

Part 2: Mass Spectrometry and the List of Prohibited Substances and Methods of Doping

• Criteria for the Mass Spectrometric Identification of Prohibited Compounds
• Modern Mass Spectrometers in Doping Controls: Advantages and Disadvantages of Available Techniques

Part 3: Structure Characterization of Low Molecular Weight Target Analytes —Electron Ionization

• Stimulants
• Narcotics
• Anabolic Androgenic Steroids
• Selective Androgen Receptor Modulators (SARMs)
• Diuretics
• β2-Agonists
• β-Receptor Blocking Agents
• Calcium-Channel Modulators (RYCALS)
• Carbohydrate-Based Agents

Part 4: Structure Characterization of Low Molecular Weight Target Analytes: Electrospray Ionization

• Stimulants
• Narcotics
• Anabolic Androgenic Steroids
• Selective Androgen Receptor Modulators (SARMs)
• Diuretics
• β2-Agonists
• Calcium-Channel Modulators (RYCALS)
• Peroxisome-Proliferator Activated Receptor-δ (PPARδ) And Adenosine Monophosphate Activated Protein Kinase (AMPK) Agonists
• Hypoxia-Inducible Factor (HIF)-Stabilizers And Sirtuin Activators
• β-Receptor Blocking Agents
• Glucuronic Acid and Sulfate Conjugates of Target Analytes

Part 5: Structure Characterization of High Molecular Weight Target Analytes: Electrospray Ionization

• Human Chorionic Gonadotrophin (hCG)
• Erythropoietins (EPO)
• Synacthen
• Insulins
• Hemoglobin-Based Oxygen Carriers (HBOCs).
• Human Growth Hormone (hGH)
• Sermorelin (Geref)
• Insulin-Like Growth Factor-1 (IGF-1)
• Gonadorelin (LHRH)

Part 6: Modern Mass Spectrometry-Based Analytical Assays

• GC-MS and Isotope Ratio Mass Spectrometry
• LC-MS/MS

Part 7: Limitations and Perspectives of Mass Spectrometry-Based Procedures in Doping Control

• Recombinant Biomolecules.
• Unknown Compounds.
• Profiling of Urine and/or Blood.
• Alternative Specimens

Index

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