Medication Treatments for Nicotine Dependence assembles contributions from leading researchers and clinicians to provide the most comprehensive volume on current and future possibilities for addressing nicotine and tobacco dependence with medication.

Features:

• Details the basic neuroscience relevant to medications development for nicotine
• Discusses current medications as well as new medications and medications classes currently in development
• Identifies the physiology, pharmacology, and psychology of tobacco addiction
• Addresses future directions, including implications for clinical practice
• Explores new biological approaches that could help define subtypes of smokers who may respond selectively to certain agents

Contents

Basic Science

• Pharmacological Effects of Nicotine and Nicotinic
• Receptor Subtype Pharmacological Profiles
• Cellular and Synaptic Effects of Nicotine
• Animal Models of Nicotine Addiction: Implications for Medications Development

First-Line Medication Treatments

• Nicotine Replacement Therapies and Other Nicotinic Strategies
• Sustained-Release Bupropion as a Pharmacological Aid to Smoking Cessation

Second-Line Medication Treatments

• Tricyclic Antidepressants in the Treatment of Nicotine Dependence
• Monoamine Oxidase Inhibitors for Smoking Cessation
• Opioid Antagonists for the Treatment of Nicotine Dependence
• Other Nonapproved Agents for Smoking Cessation

Novel Medication Treatments

• Immunological Approaches to Nicotine Addiction
• Glutamatergic Agents for Nicotine Dependence
• GABAergic Agents for the Treatment of Nicotine Dependence
• Cannabinoid Antagonists: CB1 Receptors as a Therapeutic Target for Nicotine Dependence
• Targeting the Dopamine D3 Receptor for Treatment of Nicotine Dependence
• Varenicline: An a4â2 Nicotinic Acetylcholine Receptor Partial Agonist as an Aid to Smoking Cessation

Special Topics

• Combining Medications with Behavioral Treatments
• Medication Treatments for Nicotine Dependence in Psychiatric and Substance Use Disorders
• Pharmacogenetic Approaches to the Treatment of Nicotine Dependence
• Neuroimaging of Nicotine Dependence: A Bioassay for Medications Development

Index

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