Fully understand the toxicological effects of prescription and OTC drugs on pregnant women and breastfed children.

Drawn from the internationally recognized MotherRisk program at the University of Toronto, this authoritative resource is filled with evidence-based information and guidance that puts the risks of maternal exposure to drugs into sharp focus.

The book's clear, easy-to-follow two-part organization conveniently reviews the toxicologic effects of all major drug classes, then provides well-researched, systematic reviews of major topics that impact pharmacotherapy in pregnant and breastfeeding patients. This complete guide is your best source of information-and, consequently, your patients' best defense-against the possible ill effects of reproductive and developmental drug toxicities.

Features:

• The most authoritative resource available on the maternal toxicology of prescription drugs
• Packed with evidence-based, systematic reviews of key maternal therapeutics and toxicology topics from leading peer-reviewed journals
• Complete reviews of all major drug classes, and widely used agents-plus other herbal, chemical, and radiological therapies
• Cutting-edge guidance from the world-renown MotherRisk program
• Clear, conversational tone and cohesive two-part organization that facilitates your ability to quickly identify the risks associated with specific agents and communicate this crucial information to patients
• And much more!

Contents

Part I: Rules of Thumb for Taking Drugs During Pregnancy and Breastfeeding

1. Taking drugs during pregnancy: how safe are the unsafe?
2. Which drugs are contraindicated during breastfeeding?: practice guidelines
3. Continuing drug therapy while breastfeeding: common misconcceptions of patients
4. Continuing drug therapy while breastfeeding: common misconceptions of physicians

Part II: Drug Safety—A to Z

5. Drug Safety—A to Z

Part III: Selected Drugs, Chemicals, and Medical Conditions: Frequently Asked Questions with Concise Evidence-Based Answers

6. Safe use of valproic acid during pregnancy
7. Cancer chemotherapy during pregnancy: consortium of cancer in pregnancy evidence
8. Corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDS) during pregnancy
9. Maternal obesity and prenatal risk
10. Antihistamines are apparently safe during the first trimester
11. Caffeine during pregnancy?: in moderation
12. Antiimalarial drugs for rheumatoid disease during pregnancy
13. Nicotine replacement therapy during pregnancy
14. Safety of colchicine therapy during pregnancy
15. Use of warfarin during pregnancy
16. Can we use anxiolytics during pregnancy without anxiety?: in moderation
17. Nausea and vomiting of pregnancy: evidence-based treatment algorithm
18. Can herbal products be used safely during pregnancy?
19. Taking ace inhibitors during pregnancy: is it safe?
20. Prolonged exposure to angiotensin-converting enzyme inhibitors during pregnancy. Fetal toxicity could be reversible
21. Low-molecular-weight heparins during pregnancy
22. Drinking alcohol while breastfeeding: will it harm my baby?
23. Multivitamin supplements for pregnant women: new insights
24. Folic acid and neural tube defects: good news at last!
25. Safety of gadolinium during pregnancy
26. Taking ginger for nausea and vomiting during pregnancy
27. Occupational exposure to inhaled anesthetic: is it a concern for pregnant women?
28. Using corticosteroids during pregnancy—are topical, inhaled, or systemic agents associated with risk?
29. Nonsteroidal anti-inflammatory drugs for rheumatoid arthritis during pregnancy
30. Is topical tretinoin safe during the first trimester?
31. How to ensure fetal safety when mothers use isotretinoin (accutane)
32. Young women taking isotretinoin still conceive: role of physicians in preventing disaster
33. Hypothyroidism during pregnancy
34. Effects of prenatal exposure to marijuana
35. Marijuana use and breastfeeding
36. Metformin use during the first trimester of pregnancy: is it safe?
37. Is the fetus safe when spermicides fail?
38. Acid-suppressing drugs during pregnancy
39. Counseling pregnant women who are treated with paroxetine
40. Discontinuing antidepressants and benzodiazepines upon becoming pregnant
41. Risks of untreated depression during pregnancy
42. Taking antidepressants during late pregnancy—how should we advise women?
43. Taking St. John's wort during pregnancy
44. Trimethoprim-sulfonamide combination therapy in early pregnancy
45. Influenza vaccination during pregnancy
46. Antiretroviaral treatment of maternal HIV infection

Index

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