Melanoma provides clinicaians and researchers the necessary context and perspective to integrate and effectively deploy cutting-edge therapies into daily practice.

Melanoma includes:

• synthesizes the scientific principles, clinical trial results, and clinical implications of emerging and translational melanoma therapies
• covers the entire range of translational research and therapies, including pathogenesis, progression pathways, immunotherapy, gene therapy, adjuvant therapy, surgical staging, and metastatic disease
• provides context and perspective to enable the clinician to select and use new therapies eggectively and knowledgeably

Contents

1. UV Radiation in Melanoma Development and Pathogenesis
2. Overview of Molecular Pathways in Melanoma
3. Challenging Melanocytic Neoplasms: Spitzoid Melanoma Vs. Spitz Nevus
4. Melanoma Genomics-Techniques and Implications
5. RAS Signaling in Melanoma Development and Prevention
6. Targeting BRAF Activity as a Novel Paradigm for Melanoma Therapy
7. Therapeutic Targeting of the Melanoma Stem Cell Population
8. Pigmentation Pathways and Microphtalmia-Associated Transcription Factor as New Targets in Melanoma
9. Understanding Interferon: Translating Biologic Advances into Clinical Progress
10. Predicting and Increasing Response of Melanoma to Interferon Therapy
11. New Approaches for Optimizing Melanoma Vaccines
12. Adoptive T Cell Immunotherapy
13. Procurement of Human Melanoma Specimens for Translational Research: Practical and Legal Considerations

Index

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