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Imaging Science book from C.H.I.P.S.

Metabolomics by
In Vivo NMR

by Robert G. Shulman and Douglas L. Rothman

Metabolomics by In Vivo NMR is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states.

  • Provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders
  • Novel and potentially controversial
  • Will inspire future research directions

Contents

Background

  1. Introduction (Robert G. Shulman).
  2. In Vivo NMR Spectroscopy Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations
  3. Metabolic Control Analysis for the NMR Spectroscopist

13C and 31P NMR Studies of the Regulation of Glucose Metabolism

  1. MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes
  2. Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen Synthase
  3. Regulation of Glycogen Metabolism in Muscle during Exercise
  4. 13C NMR Studies of Heart Glycogen Metabolism
  5. Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction
  6. Lactate, Glycogen and Fatigue
  7. Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty
  8. Trehalose Energetics in Yeast Spores
  9. Metabolic Networks in the Liver by 2H and 13C NMR
  10. Summarized Reflections on Metabolism

Index.

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Metabolomics by In Vivo NMR
by Robert G. Shulman and Douglas L. Rothman
2005 192 pages $179.00 + shipping
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