Metabolomics by In Vivo NMR is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states.

• Provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders
• Novel and potentially controversial
• Will inspire future research directions

Contents

Background

1. Introduction (Robert G. Shulman).
2. In Vivo NMR Spectroscopy – Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations
3. Metabolic Control Analysis for the NMR Spectroscopist

13C and 31P NMR Studies of the Regulation of Glucose Metabolism

4. MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes
5. Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen Synthase
6. Regulation of Glycogen Metabolism in Muscle during Exercise
7. 13C NMR Studies of Heart Glycogen Metabolism
8. Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction
9. Lactate, Glycogen and Fatigue
10. Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty
11. Trehalose Energetics in Yeast Spores
12. Metabolic Networks in the Liver by 2H and 13C NMR
13. Summarized Reflections on Metabolism

Index.

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ORDER NOW Metabolomics by In Vivo NMR by Robert G. Shulman and Douglas L. Rothman 2005 • 192 pages • $179.00 + shipping Texas residents please add 6.75 % sales tax