Exploring innovative routes of drug discovery in the postgenomic era, this reference examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates - exploring potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process.

Microbial Genomics and Drug Discovery describes procedures to

• recognize common targets in various bacterial species for the design of broad-spectrum antibiotics
• develop novel antibacterial compounds to combat drug resistance
• detect side effects at earlier stages in the drug discovery process
• evaluate drug candidates before the initiation of clinical trials
• perform broad-based and comprehensive cell testing in efficient and high-throughput formats using phenotype arrays

Contents

1. Global Aspects of Antibiotic Resistance
2. Genomics of Bacterial Pathogens
3. Bioinformatics, Genomics, and Antimicrobial Drug Discovery
4. The Pathway Tools Software and Its Role in Antimicrobial Drug Discovery
5. Genomic Strategies in Antibacterial Drug Discovery
6. Genomics-Based Approaches to Novel Antimicrobial Target Discovery
7. Pathogenesis Genes as Novel Targets
8. Application of Genomics to the Discovery of New Drugs Against Tuberculosis
9. Phenotype MicroArrays: Their Use in Antibiotic Discovery
10. Microbial Proteomics: New Approaches for Therapeutic Vaccines and Drug Discovery
11. Surrogate Ligand-Based Assay Systems for Discovery of Antibacterial Agents for Genomic Targets
12. Expression Profiling Uses in Antibacterial Chemotherapy Development
13. Using Fungal Genomes for the Discovery, Development, and Clinical Application of Novel and Current Antifungal Therapeutics
14. Genomics in Novel Natural Products Generation

Index

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