Micro Instrumentation Handbook from C.H.I.P.S.

Micro Instrumentation
for High Throughput Experimentation and Process Intensification - a Tool for PAT
edited by M.V. Koch

This first comprehensive treatment of the intertwined roles of micro-instrumentation, high throughput experimentation and process intensification as valuable tools for process analytical technology covers both industrial as well as academic aspects.

Micro Instrumentation provides interdisciplinary coverage ranging from chemistry and analytics to process design and engineering, supported throughout by case studies and ample analytical data.


Part I: Introducing the Concepts


  • Background
  • Analytical Tools for use in PAT
  • The Center for Process Analytical Chemistry (CPAC) and the Summer Institute
  • Topics covered by Previous CPAC Summer Institutes
  • Recent Emphasis of CPAC Summer Institutes: High Throughput Experimentation and Process Intensification

Macro to Micro … The Evolution of Process Analytical Systems

  • Chromatography

Process Intensification

  • Scope and Definitions
  • Process Intensification in the Field of Reaction Engineering
  • Process Intensification through Micro-structured Unit Operations
  • Case Studies

High Throughput Research

  • Concept of a Research Process
  • High Throughput Analytical
  • Extracting Information from the Process
  • Process Development becomes the Next Bottleneck
  • Use of High Throughput Concepts for Process Development
  • Microreactors for Process Development
  • Current Barriers and Limitations to Microscale Reaction Characterization

    Part II: Technology Developments and Case Studies

    Microreactor Concepts and Processing

    • Microreactor Technology – Interfacing and Discipline Cross-boundary Research
    • Microstructured Mixer-reactors for Pilot and Production Range and Scale-out Issues
    • Fine-chemical Microreactor Plants
    • Industrial Microreactor Process Development for Fine and Functional Chemistry
    • Industrial Production in Fine Chemistry
    • Microreactor Laboratory-scale Process Developments for Future Industrial Use
    • Free-radical Polymerizations
    • Future Directions – Establishing a Novel Chemistry by Enabling Function

    Non-reactor Micro-component Development

      ,li>Heat Exchange
    • Mixing
    • Microchannel Emulsification
    • Phase Separation
    • Phase Transfer Processes
    • Biological Processes
    • Body Force Driven Processes

    Microcomponent Flow Characterization

    • Pressure Drop
    • Dimensionless Mechanical Energy Balance
    • Entry Lengths
    • Diffusion

    Selected Developments in Micro-analytical Technology

    • Application of On-line Raman Spectroscopy to Characterize and Optimize a Continuous Microreactor
    • Developments in Ultra Micro Gas Analyzers
    • Nuclear Magnetic Resonance Spectroscopy
    • Surface Plasmon Resonance (SPR) Sensors
    • Dielectric Spectroscopy: Choosing the Right Approach
    • The Future of Liquid-phase Microseparation Devices in Process Analytical Technology
    • Grating Light Re. ection Spectroscopy: A Tool for Monitoring the Properties of Heterogeneous Matrices

    New Platform for Sampling and Sensor Initiative

    • What is NeSSI?
    • NeSSI Background
    • NeSSI Physical Layer (Generation I NeSSI)
    • NeSSI Electrical Layer (Generation II NeSSI)
    • Advantages of NeSSI in Laboratory Applications

    Catalyst Characterization for Gas Phase Processes

    • Characterizing Reactivity, Reaction Mechanisms, and Diffusion

    Integrated Microreactor System for Gas Phase Reactions

    • Microreactor Packaging
    • Microreactor System Design
    • System Control and Process Monitoring
    • Microreactor Process Safety
    • Microreactor Experimental Methods
    • AIMS Testing Results and Discussion

    Liquid Phase Process Characterization

    • System Design Basis
    • System Capabilities

    Novel Systems for New Chemistry Exploration

    • Chemical Synthesis in Microreactors
    • Chemical Synthesis in Flow Reactors

    Going from Laboratory to Pilot Plant to Production using Microreactors

    • Nitration
    • Microreaction System “MICROTAUROS.”
    • Automated Reaction Optimization
    • Upscale in Larger Laboratory Scale
    • Upscale in a Pilot Plant
    • A Concept for the Future

    Part III: A Summary and Path Forward

    Concluding Remarks

    • Summary
    • The Path Forward


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    Micro Instrumentation
    for High Throughput Experimentation and Process Intensification - a Tool for PAT
    edited by M.V. Koch

    2007 • 520 pages • $199.00 + shipping
    Texas residents please add 6.75 % sales tax
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