Modeling in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body.

Modeling in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics is divided into four parts:

• fundamental principles of fractals, diffusion and nonlinear dynamics
• drug dissolution, release, and absorption
• empirical, compartmental, and stochastic pharmacokinetic models
• nonclassical aspects of pharmacodynamics

The classical models that have relevance and application to these sciences are also considered throughout.

Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

Contents

Basic Concepts

1. The Geometry of Nature
2. Diffusion and Kinetics
3. Nonlinear Dynamics

Modeling in Biopharmaceutics

4. Drug Release
5. Drug Dissolution
6. Oral Drug Absorption

Modeling in Pharmacokinetics

7. Empirical Models
8. Deterministic Compartmental Models
9. Stochastic Compartmental Models

Modeling in Pharmacodynamics

10. Classical Pharmacodynamics
11. Nonclassical Pharmacodynamics

Index

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