Modular Protein Domains
edited by G. Cesareni

Since the full functionality of any given protein can only be understood in terms of its interaction with other, often regulatory proteins, this unique reference source covers all relevant protein domains, including SH2, SH3, PDZ, WW, PTB, EH, PH and PX.

Its user-oriented concept combines broad coverage with easy retrieval of essential information, and includes a special section on Web-based tools and databases covering protein modules and functional peptide motifs.

Modular Protein Domains is essential for the study of protein-protein interactions in vivo or in silico, and a prerequisite for successful functional proteomics studies.

Contents

1. The SH2 Domain: a Prototype for Protein Interaction Modules
2. SH3 Domains
3. The WW Domain
4. EVH1/WH1 Domains
5. The GYF Domain
6. PTB Domains
7. The FHA Domain
8. Phosphoserine/Threonine Binding Domains
9. The Eukaryotic Protein Kinase Domain
10. Structure, Specificity, and Mechanism of Protein Lysine Methylation by SET Domain Enzymes
11. The Structure and Function of the Bromodomain
12. Chromo and Chromo Shadow Domains
13. PDZ Domains: Intracellular Mediators of Carboxy-terminal Protein Recognition and Scaffolding
14. EH Domains and Their Ligands
15. Ubiquitin Binding Modules: The Ubiquitin Network Beyond the Proteasome
16. The Calponin Homology (CH) Domain
17. PH Domains
18. ENTH and VHS Domains
19. PX Domains
20. Peptide and Protein Repertoires for Global Analysis of Modules
21. Computational Analysis of Modular Protein Architectures
22. Nomenclature for Protein Modules and Their Cognate Motifs

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