This two volume Second Edition of Modified-Release Drug Delivery Technology describes the anatomical, physiological, pharmaceutical, and technological aspects of oral, colonic and rectal, ocular, oral mucosal, dermal and transdermal, nasal, vaginal, and pulmonary delivery routes.

Modified-Release Drug Delivery Technology provides insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value.

Modified-Release Drug Delivery Technology is available as a 2-volume set or each volume may be purchased individually.

Contents and information on Volume One
Contents and information on Volume Two
Ordering information

Modified-Release Drug Delivery Technology, Second edition, Volume 1

Providing insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value, topics include:

• intellectual property rights and regulatory issues and challenges
• osmotic systems and Qtrol. Qdis. Matrix Systems
• thiolated polymers for CR, Oradur. IDD technology, and chronotherapy technology
• Oral-lyn™ (RapidMist™ Technology)
• Dentipatch drug delivery system
• ORAVESCENT™: a novel technology for the transmucosal delivery of drugs
• Egalet and COLAL technologies...and more!

Contents of Volume 1

Part I: Intellectual Property Rights

1. Patent and Other Intellectual Property Rights in Drug Delivery
2. Intellectual Property Developments and Issues in India
3. Parameter Claims at the European Patent Office
4. Japan's Patent Issues Relating to Modified Drug Delivery Technology

Part II: Oral Mucosal Technologies

5. Oral Transmucosal Drug Delivery
6. Pilocarpine Buccal Insert
7. OraVescent® Drug Delivery System: A Novel Technology for the Transmucosal Delivery of Drugs
8. DentiPatch® Development
9. Medicated Chewing Gum
10. The Oral PowderJect Device for Mucosal Drug Delivery
11. The PerioChip™: A Biodegradable Device for the Controlled Delivery of Chlorhexidine in the Subgingival Environment

Part III: Oral Technologies

12. Modified-Release Delivery Systems for Oral Use
13. Advances in Cellulose Ether-Based Modified-Release Technologies
14. SQZgel™
15. Thiolated Polymers for Controlled Release
16. Two Concepts, One Technology: Controlled-Release Solid Dispersions Using Melt Extrusion (Meltrex®)
17. Threeform—Technology for Controlled Release of Amorphous Active Ingredient for Once-Daily Administration
18. Floating Gastroretentive Capsule for Controlled Drug Delivery
19. Thin Film Oral Dosage Forms
20. Dose Sipping Technology—A Novel Dosage Form for the Administration of Drugs
21. Enhances Gastroretentive Dosage Form with Minimal Food Effects: GIRES™
22. Advancing Gastrointestinal Permeation Enhancement Formulations into the Flinic: GIPET™
23. The Micropump® Technology
24. A Novel Micropattical Technology for Tailored Drug Release in the Gastrointestinal Tract
25. Lipid Nanoparticles (SLN, NLC, LDC) for the Enhancement of Oral Absorption

Part IV: Colonic Technologies

26. Colonic Drug Delivery
27. Biopolymers and Colonic Delivery
28. Enteric Coating for Colonic Delivery
29. Programmed Drug Delivery Systems and the Colon
30. Pulsincap™ and Hydrophilic Sandwich Capsules: Innovative Time-Delayed Oral Drug Delivery Technologies
31. Targeting the Colon Using COLAL™: A Novel Bacteria-Sensitive Drug Delivery System
32. Development of the Egalet Technology

Part V: Regulatory Issues and Challenges

33. Regulatory Aspects in Modified-Release Drug Delivery
34. Regulatory Issues in the United States Relating to Modified-Release Drug Formulations
35. Japanes Regulatory Issues on Modified-Release Drug Products
36. Regulatory Aspects of Delivery Systems in the European Union
37. Canadian Regulatory Requirements for Drug Approval
38. Regulating Modified-Release Drug Delivery Technologies in Australia

Index

Modified-Release Drug Delivery Technology, Second edition, Volume 2

Topics for Volume 2 include:

• modified drug release landscape; academic, regulatory, and intellectual property viewpoints
• I-vation Sustained Release Intravitreal System
• ViaNase Intranasal Device and controlled particle dispersion technology Platform
• Microneedles for drug delivery, PassPort system, dot-matrix technology, ultrasound, iontophoretic and technologies
• DirectHaler nasal technology
• intravaginal ring systems, Supravail, Vagisite, C-Vad™ Vaginal Insert, and 'Smart' Vaginal Delivery Systems
• the AERx® Pulmonary Drug Delivery System
• AAD-Adaptive aerosol delivery technology
• nebulizer technologies, microdose propietary, and dry powder inhaler...and much more!

Contents of Volume 2

Part I: Using Modified-Release Formulations to Maintain and Develop Markets

1. The Modified Drug Release Landscape: The Commercial Perspective
2. The Modified Drug Release Landscape: Academic Viewpoint
3. The Modified Drug Release Landscape: Advantages and Issues for Physicians and Patients
4. The Modified Drug Release Landscape: Drug Delivery Commercialization Strategies

Part II: Ocular Technologies

5. Ophthalmic Drug Delivery
6. Intraocular Implants for Controlled Drug Delivery
7. Bioadhesive Ophthalmic Drug Inserts (BODI) for Veterinary Use
8. Ion Exchange Resin Technology for Ophthalmic Applications

Part III: Injection and Implant Technologies

9. Injections and Implants
10. Long-Acting Protein Formulation—PLAD Technology
11. Long-Term Controlled Delivery of Therapeutic Agents by the Osmotically Drive DUROS® Implant
12. The SABER™ Delivery System for Parenteral Administration
13. Improving the Delivery of Complex formulations Using the DepotOne® Needle
14. ReGel Depot technology
15. The Atrigel® Drug Delivery System
16. Enhancing Drug Delivery by chemical Modification
17. DepoFoam® Multivesicular Liposomes for the Sustained Release of Macromolecules
18. ALZAMER® Depot™ Bioerodible Polymer Technology
19. Pegylated Liposome Delivery of Chemotherapeutic Agents: Rationale and Clinical Benefit

Part IV: Dermal and Transdermal Technologies

20. Dermal and Transdermal Drug Delivery
21. ALZA Transdermal Drug Delivery Technologies
22. Microneedles for Drug Delivery
23. Transfersome®: Self-Optimizing and Self-Driven Drug-Carrier
24. Advances in Wound Healing
25. Ultrasound-Mediated Transdermal Drug Delivery
26. Lipid Nanoparticles with Solid Matrix for Dermal Delivery: Solid Lipid Nanoparticles and Nanostructured Lipid Carriers
27. LidoSite®—Vyteris Iontophoretic Technology
28. Nail Delivery
29. Immediate Topical Drug Delivery Using Natural Nano-Injectors
30. DOT Matrix® Technology
31. The PassPort™ System: A New Transdermal Patch for Water-Soluble Drugs, Proteins, and Carbohydrates

Part V: Nasal Technologies

32. Nasal Drug Delivery
33. Controlled Particle Dispersion®: A Twenty-First-Century Nasal Drug Delivery Platform
34. DirectHaler™ Nasal: Innovative Device and Delivery Method

Part VI: Vaginal Technologies

35. Intravaginal Drug Delivery Technologies
36. Vaginal Rings for Controlled-Release Drug Delivery
37. Phospholipids as Carriers for Vaginal Drug Delivery
38. SITE RELEASE® Vaginal Bioadhesive System
39. Clindamycin Vaginal Insert
40. Bioresponsive Vaginal Delivery Systems

Part VII: Pulmonary Technologies

41. Pulmonary Delivery of Drugs by Inhalation
42. AERx® Pulmonary Drug Delivery System
43. Formulation Challenges of Powders for the Delivery of Small Molecular Weight Molecules as Aerosols
44. Adaptive Aerosol Delivery (AAD®) Technology
45. Nebulizer Technologies
46. Formulation Challenges: Protein Powders for Inhalation
47. The Respimat®, A New Soft Mist™ Inhaler for Delivering Drugs to the Lungs
48. Pressurized Metered Dose Inhalation Technology
49. Dry Powder Inhalation Systems from Nektar Therapeutics
50. Technosphere®/Insulin: Mimicking Endogenous Insulin Release

Index

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