Introduction to Biochemical Toxicology is an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels.

Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth edition.

This new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style.

Additional features of this new edition include:

• New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics
• Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters
• Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity

Contents

1. Molecular and Biochemical Toxicology: Definition and Scope
2. Overview of Molecular Techniques in Toxicology: Genes and Transgenes
3. Toxicogenomics
4. Proteomics
5. Metabolomics
6. Bioinformatics
7. Immunochemical Techniques in Toxicology
8. Cellular Techniques
9. Structure, Mechanism and Regulation of Cytochromes P450
10. Phase I Metabolism of Toxicants and Metabolic Interactions
11. Phase I-Pharmacogenetics
12. Phase II-Conjugation of Toxicants
13. Regulation and Polymorphisms in Phase II Genes
14. Developmental Effects on Xenobiotic Metabolism
15. Cellular Transport and Elimination
16. Mechanisms of Cell Death
17. Mitochondrial Dysfunction
18. Glutathione-Dependent Mechanisms in Chemically Induced Cell Injury and Cellular Protection Mechanisms
19. Toxicant-Receptor Interactions: Fundamental Principles
20. Reactive Oxygen/Reactive Metabolites and Toxicity
21. Metals
22. DNA Damage and Mutagenesis
23. DNA Repair
24. Carcinogenesis
25. Genetic Toxicology
26. Molecular Epidemiology and Genetic Susceptibility
27. Respiratory Toxicology
28. Hepatotoxicity
29. Biochemical Mechanisms of Renal Toxicity
30. Biochemical Toxicology of the Peripheral Nervous System
31. Biochemical Toxicology of the Central Nervous System
32. Immunotoxicology
33. Reproductive Toxicology
34. Developmental Toxicology
35. Dermatotoxicology

Index

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