Molecular Carcinogenesis and the Molecular Biology of Human Cancer provides a technical, as well as historical, overview of research covering the science of cancer.

Features:

• Offers a readily understandable exploration of the basic chemistry and biochemistry of chemical carcinogenesis
• Uses basic science principles to explain organ system concerns with regard to cancer
• Explores the human implications of data derived from experiments with transgenic and knockout mice and rats
• Includes numerous charts that help summarize and clarify information

Contents

• Carcinogens and Mutagens
• Whole Animal Carcinogenicity Bioassays
• Molecular Mechanisms of Action of Selected Organic Carcinogens
• Binding of Carcinogens to DNA and Covalent Adducts and DNA Damage- PAH, Aromatic Amines, Nitro-aromatic Compounds, and Halogenated Compounds
• Cellular Oncogenes and Carcinogenesis
• Tumor Suppressor Genes
• Hepatitis B, Hepatitis C, and Hepatocellular Carcinoma
• Oncongenesis in Transgenic and Knockout Mice
• Chemically Induced Morphological and Neoplastic Transformation in C3H/10T1/2 Cl 8 Mouse Embryo Cells
• Radiation Carcinogenesis
• DNA Microarrays and Computational Analysis of DNA Microarray Data in Cancer Research
• Application of Proteomics in Basic Biological Sciences and Cancer
• Overview of Human Cancer Induction and Human Exposure to Carcinogens
• Complex Mixtures of Chemical Carcinogens: Principles of Action and Human Cancer
• Lung Cancer
• Breast Cancer
• Cancer of the Prostate- Mechanisms of Molecular Carcinogenesis
• Skin Cancer: Epidemiology, Clinical Manifestations, and Genetic and Molecular Aspects
• Cell and Molecular Biology of Cancer of the Brain
• Thyroid Cancer: Molecular Biology and Clinical Aspects
• Chemoprevention of Chemical Carcinogenesis and Human Cancer
• Carcinogen Biomarkers and Exposure Assessment
• Risk Assessment for Chemical Carcinogens
• Prevention and Regulation Approaches to Carcinogens

Index

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