Molecular Mechanisms of Cardiac Hypertrophy and Failure highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature.

Features:

• Discusses key advances in biomedical research and their impact on clinical studies
• Reviews each topic in depth, providing background and perspective on current literature
• Puts new developments in a broader context, permitting comparison of different ideas and careful evaluation of their importance
• Includes contributions from expert opinion leaders at recognized centers of excellence

Contents

Mechanisms for Cardiac Hypertrophy

• Mechanisms for Normal CV Growth and Development
• Cell Cycle Control
• Apoptosis
• G-Protein Coupled Receptors
• Mechanotransduction
• Extracellular Matrix
• Physiologic vs. Pathologic Hypertrophy
• Abnormal Signal Transduction
• Tissue Regeneration

Mechanisms for Contractile Depression

• Normal Excitation Contraction Coupling and Calcium Homeostasis
• Calcium Homeostasis
• Myocardial Ischemia and Infarction
• Cardiac Remodeling
• Inflammation
• Phosphorylation/Dephosphorylation
• Cytoskeleton
• Environmental Factors in Cardiac Hypertrophy and Failure

Electrical Properties

• Normal Action Potential Generation Propagation and Repolarization
• Depolarization Abnormalities
• Repolarization Abnormalities
• Cell-Cell Transmission Abnormalities

Genetic Basis for Cardiomyopathy

• Genomic Analysis
• Monogenetic Abnormalities
• Polygenic Abnormalities and the Roles of Transcriptional Profiling and Proteomics

Index

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