Molecular Chaperones in Health and Disease covers the analysis of the mode of action of chaperones at the molecular, cellular and organismic level and then describes specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
This volume provides a balanced view as well as specific and detailed information on most of the topics of interest for those professionals involved in experimental and therapeutic approaches of pharmacological modulation of heat shock response and chaperone action.
Molecular Chaperones in Health and Disease is a volume in the series Handbook of Experimental Pharmacology.
Contents
- Chaperones in Preventing Protein Denaturation in Living Cells
and Protecting Against Cellular Stress
- Feedback Regulation of the Heat Shock Response
- Protein Folding in the Endoplasmic Reticulum
and the Unfolded Protein Response
- Molecular Chaperones in Signal Transduction
- Chaperoning of Glucocorticoid Receptors
- Heat Shock Response: Lessons from Mouse Knockouts
- HSFs in Development
- Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death
- Protein Aggregation as a Cause for Disease
- The Role of Chaperones in Parkinson’s Disease and Prion Diseases
- Chaperoning Oncogenes: Hsp90 as a Target of Geldanamycin
- Heat Shock Proteins in Immunity
- Molecular Chaperones and Cancer Immunotherapy
- Hsp90 Inhibitors in the Clinic
- Pharmacological Targeting of Catalyzed Protein Folding:
The Example of Peptide Bond cis/trans Isomerases
- Chemical Chaperones: Mechanisms of Action and Potential Use
- Pharmacological Modulation of the Heat Shock Response
Index
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