Medical book from C.H.I.P.S.

Molecular Mechanisms of Atherosclerosis
edited by
Joseph Loscalzo

Molecular Mechanisms of Atherosclerosis:

  • Delineates the current view of molecular and cellular basis of the process of atherosclerosis
  • Features illustrative figures that address the fundamental mechanisms underlying atherosclerosis
  • Presents an authoritative overview of key advances in biomedical research
  • Reviews each topic in depth, providing background and perspective on current literature
  • Discusses new developments in a broader context, permitting comparison of different ideas and evaluation of their importance
Atherosclerosis is the most common cardiovascular disorder in western societies and is rapidly becoming similarly prevalent in the underdeveloped world.

Molecular Mechanisms of Atherosclerosis addresses the fundamental mechanisms underlying atherothrombosis and delineates current views of the molecular and cellular basis of the process.

Molecular Mechanisms of Atherosclerosis approaches the issue from a mechanistic perspective, and does so in the context of contemporary knowledge of molecular and cellular pathobiology.

Molecular Mechanisms of Atherosclerosis provides an epidemiological overview of atherosclerotic vascular disease, followed by a review of the genetics and genetic epidemiology.

It focuses on the four fundamental mechanisms common to all risk factors for atherosclerosis: inflammation, oxidative stress, thrombosis, and endothelial dysfunction and the mechanisms under lying for common risk factors for atherogenesis: dyslipidaemias, diabetes mellitus, hypertension, and smoking.

Molecular Mechanisms of Atherosclerosis then discusses the recently proposed risk factors hyperhomocysteinemia and infection and rational molecular therapies to prevent and combat established atherothrombotic disease.

Taken together, these chapters offer a broad review of the molecular and cellular mechanisms of atherothrombogenesis.

The topics covered and the order of presentation were carefully chosen to clarify the complexity of the disease process.

Armed with the information contained in this text, you can confidently explore cutting-edge research with insight and foresight regarding their implications for prevention and treatment.


  1. Introduction and overview
  2. The epidemiology of atherosclerotic disease
  3. Genetics of atherosclerosis in humans
  4. Inflammation and atherothrombosis
  5. Oxidative stress and atherosclerosis
  6. Thrombosis and atherosclerosis
  7. Endothelial dysfunction in atherosclerosis : mechanisms of impaired nitric oxide bioactivity
  8. Lipoproteins and atherogenesis
  9. Diabetes mellitus as an atherogenic factor
  10. Hypertension and atherogenesis
  11. Smoking and the molecular mechanisms of atherogenesis
  12. Homocysteine and atherogenesis
  13. Infection and atherogenesis
  14. Rational contemporary molecular and cell-based therapies
  15. Future directions

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Molecular Mechanisms of Atherosclerosis
edited by Joseph Loscalzo

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