Molecular Epidemiology of Chronic Diseases crosses the disciplinary boundaries between laboratory scientists, epidemiologists, clinical researchers and biostatisticians and is accessible to all these relevant research communities in focusing on practical issues of application, rather than reviews of current areas of research.

Molecular Epidemiology of Chronic Diseases provides an easy-to-use, clearly presented handbook that allows epidemiologists to understand the specifics of research involving biomarkers, and laboratory scientists to understand the main issues of epidemiological study design and analysis.

Contents

1. Introduction: why molecular epidemiology
2. Study design
3. Molecular epidemiological studies that can be nested within cohorts
4. Family studies, haplotypes and gene association studies
5. Individual susceptibility and gene-environment interaction
6. Biomarker validation
7. Exposure assessment
8. Carcinogen metabolites as biomarkers
9. Biomarkers of exposure: adducts
10. Biomarkers of mutation and DNA repair capacity
11. High-throughput techniques - genotyping and genomics
12. Proteomics and molecular epidemiology
13. Exploring the contribution of metabolic profiling to epidemiological studies
14. Univariate and multivariate data analysis
15. Meta-analysis and pooled analysis - genetic and environmental data
16. Analysis of complex datasets
17. Some implications of random exposure measurement errors in occupational and environmental epidemiology
18. Bioinformatics
19. Biomarkers, disease mechanisms and their role in regulatory decisions
20. Biomarkers as endpoints in intervention studies
21. Biological resource centres in molecular epidemiology: collecting, storing and analysing biospecimens
22. Molecular epidemiology and ethics: biomarkers for disease susceptibility
23. Biomarkers for dietary carcinogens: the example of heterocyclic amines in epidemiological studies
24. Practical examples 2: hormones
25. Aflatoxin, hepatitis B virus and liver cancer: a paradigm for molecular epidemiology
26. Complex exposures - air pollution

Index

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