Molecular Mechanisms in Hypertension covers the latest advances in the areas of biomedical research that are at the interface of science and clinical medicine, where new discoveries in genetics, molecular and cell biology are finding application in the development of new drugs or the implementation of new kinds of therapy.

Contents

Part I: Renin / Angiotnsin /Aldosterone Systems

1. Biology of AII (Synthesis, Degradation, Measurement, Fragments and A1-7, AIV, ACE2, Inflammation, Coagulation, Angiogenesis)
2. Actions of AII
3. Actions of Aldsterone
4. Biology of Renin/Prorenin/Renin Exon 1A/Direct Renin Action, Renin Synthesis
5. Circulating RAAS
6. Tissue RAASs

Part II: Renal Mechanisms in Hypertension

7. Pressure Naturesis
8. Intraglomerular Pressure and Nephron Loss
9. Nephron Number and BP
10. Renal Prostaglandins/Depressors and BP
11. Role of Dopamine
12. Modulator and Non-Modulator Hypertension
13. TGF and BP
14. Renal Causes of Secondary Hypertension
15. ACE Inhibitor Prevention of Hypertension
16. Other Mechanisms

Part III: Endocrine Hypertension

17. Adrenocortical Hypertension
18. Adrenergic Nervous System
19. Pheochromocytoma
20. Other Endocrine Causes of Hypertension

Part IV: Non-Ras Peptides

21. Vasopressin and Neuropeptide Y, Calcitonin GRP, Leptin
22. Natriuretic Factors
23. Endothelin
24. Kinins/ACE Substrates

Part V: Secondary Messengers and the Sequelae of Hypertension

25. Signal Transduction
26. Regulation of Blood Flow (incl TGF)
27. Vascular Distensability, Pulse Pressure, and Vascular Pathology
28. Myogenic Regulation and BP
29. Regression of Vascular Hypertrophy
30. Left Ventricular Hypertrophy Onset/Regression/Remodeling/Fibrosis
31. Nitric Oxide/Oxidative Stress/Endothelial (Dys)Function
32. Prostaglandins, Lypoxigenase Products and BP Control
33. Endogenous Na/K ATPase Inhibitors

Part VI: Genomics, Proteomics and Hypertension

34. Gene Regulation, Hypertension, Hypertensive Sequelae
35. Genomic Microarrays and Hypertension
36. Transgenic and Knock-Out Models of Hypertension
37. Application of Antisense and Sirna to the Study of Hypertension
38. Heritable Monogenic Forms of Hypertension (Liddle's etc, Laidlaw's etc)
39. Genetics of Hypertension
40. Gene Therapy and Hypertension
41. Proteomics and Hypertension
42. The Proteosome and the Development of Hypertensive Sequelae
43. Apoptosis and the Sequelae of Hypertension
44. Stem Cells and Cardiovascular Structure

Part VII: Other Issues

45. Sodium and Potassium in Hypertension]
46. Divalent Cations/ Hypertension
47. Birthweight and Hypertension
48. Baroreflexes

Index

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