Molecular Pathology in Drug Discovery and Development covers powerful new tools for drug development.

Molecular pathology offers tools and techniques that can greatly enhance the drug discovery and development process, helping to make the promises of personalized medicine a reality. Molecular Pathology in Drug Discovery and Development provides an unmatched guide to this cutting-edge discipline and its applications to pharmaceutical science.

This reference offers both an overview of molecular pathology and a close look at the methods as they are applied to the process of drug discovery and development. Presented as steps in the drug development process, the coverage includes the use of molecular pathology to:

• Identify and validate new drug candidates
• Enhance transcriptional profiling to better find and validate biomarkers
• Assess toxicology
• Employ toxicogenomics to identify genes relevant to the safety of compounds
• Identify correct doses for different drugs
• Identify patients for treatment
• Develop molecular therapies
• Further the new techniques of Immunohistochemistry and Immunofluorescence

Contents

1. 1 MOLECULAR PATHOLOGY AND DRUG DEVELOPMENT
2. MOLECULAR PATHOLOGY IN ONCOLOGY TARGET AND DRUG DISCOVERY
3. MOLECULAR PATHOLOGY AND TRANSCRIPTIONAL PROFILING IN EARLY DRUG DEVELOPMENT
4. MOLECULAR PATHOLOGY IN NONCLINICAL SAFETY ASSESSMENT
5. TOXICOGENOMICS IN DRUG DEVELOPMENT
6. MOLECULAR PATHOLOGY AS A WAY TO FIND THE RIGHT DOSE FOR A DRUG
7. MOLECULAR PATHOLOGY IN LIFE-CYCLE MANAGEMENT IN DRUG DEVELOPMENT
8. MOLECULAR PATHOLOGY AND MOLECULAR THERAPY
9. MOLECULAR PATHOLOGY: IMMUNOHISTOCHEMISTRY ASSAYS IN DRUG DEVELOPMENT PERFORMED BY A CONTRACT RESEARCH LABORATORY
10. QUANTIFICATION OF MOLECULAR PATHOLOGY: COLORIMETRIC IMMUNOHISTOCHEMISTRY
11. AQUA® TECHNOLOGY AND MOLECULAR PATHOLOGY

Index

click here to see books • videos • cd-roms of related interest