Mouse Models of Human Cancer
edited by Eric C. Holland

Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field.

Offering a survey of the latest research and a description of future areas of interest, this text:

• Presents real experimental data
• Describes organ site-specific mouse models
• Clearly identifies suitable models for further drug testing
• Critically analyzes current methodologies and their limitations
• Features numerous recognizable expert contributors
• Lists key Web sites, reagents, and companies

From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions.

Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Contents

1. Mouse Handling and Engineering
   1. Approaches to Handling, Breeding, Strain Preservation, Genotyping, and Drug Administration for Mouse Models of Cancer
   2. Pathology of Mouse Models of Cancer
   3. Intercurrent Infections in Genetically Engineered Mice
   4. Germline Modification Strategies
   5. Somatic Cell Gene Transfer

2. Organ Site-Specific Mouse Models of Human Cancer
   6. Lung Cancer
   7. Mammary Gland Cancer
   8. Prostate Cancer
   9. Skin Cancer
   10. Ovarian Cancer
   11. Peripheral Nervous System Tumors
   12. Central Nervous System Tumors
   13. Myeloid Malignancies
   14. Lymphoid Malignancies

3. General Issues in Cancer Biology
   15. Genetic Modifiers
   16. Modeling Blood Vessel Formation in the Mouse
   17. Metastasis
   18. Immunologic Study of Tumors in Mouse Models

4. Imaging Technologies
   19. Micro–Computed Tomography of Mouse Cancer Models
   20. Magnetic Resonance Imaging in Mouse Cancer Models
   21. Bioluminescent Imaging of Mouse Cancer Models

5. Preclinical Trials
   22. Use of Magnetic Resonance Imaging for Evaluation of Treatment Response
   23. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling
   24. Trial Design and Biostatistics
   25. Cancer Drug Development in the Modern Era
   26. Preclinical Trials in Mouse Cancer Models

Index

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