Mass Spectrometry in Drug Metabolism and Pharmacokinetics discusses mass spectrometry in drug metabolism and pharmacokinetic studies.

With contributions by professionals from the pharmaceutical industry, Mass Spectrometry in Drug Metabolism and Pharmacokineticsbegins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics.

Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book focuses on the use of LC/MS and MALDI-MS.

Contents

1. The Evolving Role of Mass Spectrometry in Drug Metabolism and Pharmacokinetics
2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications
3. Triple Quadrupole and Hybrid QQQ/LIT Mass Spectrometers in Metabolite Analysis
4. Applications of Quadrupole-Time-of-Flight Mass Spectrometer in Reactive Metabolite Screening
5. Changing Role of FTMS for Drug Metabolism Applications
6. High Resolution LC-MS Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection
7. Applications of High Sensitive Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies
8. LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-oxide, and Hydroxylated Analogs of Desloratadine
9. On-Line Electrochemical/LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants
10. Turbulent Flow LC-MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification
11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules
12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals

Index

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