Mucus Hypersecretion in Respiratory Disease draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem.

Mucus Hypersecretion in Respiratory Disease includes:

• epidemiology
• airways infection and mucus hypersecretion
• the genetics and regulation of mucus production
• models of mucus hypersecretion
• the implications of new knowledge for the development of novel therapies

Contents

1. Epidemiological studies in mucus hypersecretion
2. Post-secretory fate of host defence components in mucus
3. Mechanisms of submucosal gland morphogenesis in the airway
4. Mucin-producing elements and inflammatory cells
5. Respiratory tract mucins: structure and expression patterns
6. Development and validation of a lectin-based assay for the quantitation of rat respiratory mucin
7. Regulation of mucin secretion from in vitro cellular models
8. Oscillations of pH inside the secretory granule control the gain of Ca2+ release for signal transduction in goblet cells exocytosis
9. A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction
10. Mechanisms by which Gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR)
11. Non-allergic models of mu cous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways
12. Cytokine regulation of mucus production in a model of allergic asthma
13. The role of apoptotic regulators in metaplastic mucous cells
14. Current and future therapies for airway mucus hypersecretion
15. Clinical evaluation of new therapies for treatment of mucus hypersecretion in respiratory diseases

Index

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